Thesis supervisor: Dezső Szikra
Location of studies (in Hungarian): Department of Medical Imaging, Nuclear Medicine, University of Debrecen Abbreviation of location of studies: 111
Description of the research topic:
Small and medium scale medical cyclotrons have widespread use for the production of 18F and 11C isotopes. These are commonly used for the production of tracers for the diagnosis of oncological- and neurological diseases. Radiometals have favourable physical and chemical properties, enabling the tracking of slower biological processes and performing isotope therapy, but these are available only in specialised research centers with large cyclotrons. The special features of radiometals necessiates the development of appropriate technology for their production in cyclotron. The aim of our work is the development of new production and purification methods of various radiometals (44Sc, 68Ga, 205/206Bi, 52Mn etc.) and their application for radiolabeling of biomolecules. We systematically study the effects of target construction and irradiation on the yield- and radionuclidic impurity profile of the produced isotopes. We develop methods for the remote controlled processing of irradiated targets, and automatize the separation of the produced isotope from the target material.. We develop and apply automatized flow chemistry methods for the optimization of labeling reactions with different chelators.
Required language skills: english Further requirements: radiochemical experience
Number of students who can be accepted: 1
Deadline for application: 2019-01-15
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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