ODT - THESIS TOPIC: Ágnes Tantos: Protein-RNA complexes in the ...


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Thesis topic proposal

Protein-RNA complexes in the regulation of epithelial-mesenchymal transition

THESIS TOPIC PROPOSAL

Institute: Eötvös Loránd University, Budapest
biology
Doctoral School of Biology

Thesis supervisor: Ágnes Tantos
Location of studies (in Hungarian): Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences
Abbreviation of location of studies: MTA

Description of the research topic:

The first step in the metastasis formation of cancer tissues is the epithelial-mesenchymal transition (EMT). One well known phenomenon in the background of EMT is the reduction in the E-cadherin level, achieved by the concerted actions of the Snail transcription factor and the Polycomb Repressive Complex 2 (PRC2). This process involves a long non-coding RNA, HOTAIR, that is capable of binding both Snail and several components of the PRC2. The main goal of the project is to give a detailed structural characterisation of the complexes of HOTAIR and its different partners (Snail, Ezh2 and Suz12) and the deeper understanding of the signal transduction pathways that regulate them.

Required language skills: fluent English (at least B2)
Further requirements:
MSc degree

Number of students who can be accepted: 1

Deadline for application: 2018-05-31

2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).