Thesis supervisor: Gitta Schlosser
Location of studies (in Hungarian): ELTE, Institute of Chemistry Abbreviation of location of studies: ELTE
Description of the research topic:
Posttranslational modifications determine the structure, function and activity of proteins. Citrullination or deimination is an irreversible posttranslational modification of proteins, in which arginine (Arg) residues are converted to citrulline (Cit) residues in an enzyme-catalyzed reaction. Citrullinated proteins can be detected in elevated levels in certain autoimmune and inflammatory diseases, neurodegenerative diseases and in cancer. The aim of the proposed research work is the exploration of the specificity and kinetics of the enzymatic conversion to have detailed information about the physico-chemical parameters regulating the formation of deiminated residues in biopolymers. Experimental strategy is based on oligopeptides, which will be synthesized using solid-phase peptide synthesis. Peptides will be analyzed in a novel HPLC-MS(/MS)-based experimental workflow.
Required language skills: English Further requirements: Experience in analytical chemistry or in organic chemistry
Number of students who can be accepted: 1
Deadline for application: 2018-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
Login
