Thesis supervisor: Tamás Horváth
co-supervisor: Bence Rácz
Location of studies (in Hungarian): University of Veterinary Medicine Budapest Abbreviation of location of studies: ÁTE
Description of the research topic:
Our overall goal is to understand the biological underpinning of the beneficial effects of calorie restriction on integrative physiology, including complex behaviors and peripheral tissue functions. We specifically hypothesize that hypothalamic neurons responsible for appetite and feeding control play crucial roles in mediating the effects of calorie restriction on behaviors, the immune system, bone metabolism, the adipose tissue and overall health- and lifespan. We developed a set of studies where we directly and forcefully interrogate these novel concepts using animal models. We designed these studies based on extensive previously published work and results that we have generated but not yet published. The execution of our studies will shed new light on integrative physiology and molecular principles of calorie restriction-induced alterations in health- and lifespan. Beyond this specific outcome, our studies will deliver novel principles for integrative physiology where the hypothalamus plays an organizational role to align behavior with appropriate peripheral functions.
As most developed societies have aging populations, the scope of this work is of direct relevance for international biomedicine. The proposed state-of-the-art experimental approaches will deliver results that will be of broad interest, and therefore, we anticipate publishing our results in the highest impact scientific journals. Because of the use of cutting edge technology in a university setting, we also believe that our studies will provide a unique platform to train next generation scientists.
Required language skills: english Further requirements: DVM, MD or biology MSc degree, confident knowledge of English, high qualified school achievement. Interest and understanding of the topic. Interest in laboratory work, histochemistry, immunocytochemistry and microscopy. Basic knowledge of physiology.
Number of students who can be accepted: 1
Deadline for application: 2018-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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