ODT - THESIS TOPIC: Csilla Laczka: Organic Anion Transporting Polypeptides ...


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Thesis topic proposal

Organic Anion Transporting Polypeptides as new pharmacological targets

THESIS TOPIC PROPOSAL

Institute: Eötvös Loránd University, Budapest
biology
Doctoral School of Biology

Thesis supervisor: Csilla Laczka
Location of studies (in Hungarian): Enzimológiai Intézet, MTA TTK, Budapest
Abbreviation of location of studies: MTA

Description of the research topic:

Organic Anion Transporting Polypeptides (OATPs) are membrane proteins that mediate the uptake of large anionic or amphipatic organic molecules. In addition to their transport of endogenous compounds (bile acids, bilirubin and various hormones), several members of the family are also able to transport clinically applied drugs (e.g. statins, antivirals, chemotherapeutics). Therefore OATPs may influence the in vivo fate of drugs. In addition to their physiological relevance, altered expression or function of OATPs has also been documented in cancer. Hence OATPs are potential targets in anti-cancer therapy. Our major interest is the elucidation of the role of OATPs in chemotherapy response. Additionally, we are investigating newly identified OATP variants with yet undefined physiological or pharmacological role.

Required language skills: English
Number of students who can be accepted: 2

Deadline for application: 2018-05-31

2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).