Thesis supervisor: Csaba Pál
Location of studies (in Hungarian): Biological Research Centre of the Hungarian Academy of Sciences, Institute of Biochemistry, Synthetic and Systems Biology Unit, Csaba Pál Laboratory Abbreviation of location of studies: SzBK
Description of the research topic:
The discovery of new antibiotics has slowed down significantly over the past 50 years, while the spread of multidrug-resistant bacteria is an increasing public health hazard. Antimicrobial peptides could be promising novel drug candidates against multidrug-resistant infections, however, in the absence of systems-level investigations, the development of peptide-based drug candidates is slow and often inefficient. The systematic investigation of the evolution of antimicrobial peptide resistance enables us to identify peptides, which could serve as a starting point for the development of resistance-free drug candidates. Moreover, by the examination of the evolutionary interactions ideal peptid-antibiotic combinations could be found that are effective against multidrug-resistant pathogenic bacteria.
The project will require a high-throughput evolutionary experiment to study how and to what extent bacteria can develop resistance towards a divers set of antimicrobial peptides. Moreover, the project will include the systematic investigation of the evolutionary interactions of antimicrobial peptide resistant bacteria towards other peptides as well as conventional antibiotics.
During the implementation of this project, the PhD student will learn the latest approaches from molecular and systems biology and utilize state-of-the-art synthetic biology methods and computational analysis.
Required language skills: ood written and spoken English Recommended language skills (in Hungarian): English B2 Further requirements: Laboratory experience in microbiology, molecular biology and/or synthetic biology
Number of students who can be accepted: 1
Deadline for application: 2018-09-26
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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