Thesis supervisor: Ernő Zádor
Location of studies (in Hungarian): Institute of Biochemistry, Faculty of Medicine, University of Szeged Abbreviation of location of studies: SzTE
Description of the research topic:
Skeletal muscle is very amenable for studying differentiation and adaptation. Our research group has developed several experimental models in the past twenty years. We investigated the effect of regeneration, denervation and passive movement on gene expression. We showed the change in levels of sarcoplasmic reticulum calcium pumps in diabetic muscle and demonstrated the muscle and fibre specific growth stimulating effect of 20-hydroxyecdysone, a phytoecdysteroid and insect moulting hormone. Recently the main track of interest is the transgenic skeletal muscle, particularly a phenomenon that transfecting only a few myonuclei within a few fibres with certain transgenes will increase growth in the whole regenerating muscle by activating autocrine-paracrine processes. The transfected genes so far have interfered with the calcium metabolism and the Ras pathway, our aim is to identify further players in this novel process (described first by our group).
Required language skills: English B2 Recommended language skills (in Hungarian): Hungarian Number of students who can be accepted: 1
Deadline for application: 2018-09-26
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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