Thesis supervisor: Imola Wilhelm
co-supervisor: István Krizbai
Location of studies (in Hungarian): Institute of Biophysics, Biological Research Centre, Hungarian Academy of Sciences Abbreviation of location of studies: SZBK
Description of the research topic:
Brain metastases of malignant tumors are life threatening pathologies with limited therapeutic options. Therefore, besides surgical removal of the primary tumor, suppressing or reducing the risk of metastasis formation could be one of the most effective approaches in the therapeutic strategies. Since the cerebral parenchyma lacks a lymphatic vasculature, the only possibility for cancer cells to reach the brain is via the blood stream. Metastatic cells invading the CNS parenchyma thus have to pass the blood-brain barrier (BBB). Tumors giving CNS metastases with the highest frequencies are malignant melanoma, lung cancer and breast cancer. By using an in vitro model of the BBB the project is focused on the elucidation of molecular mechanisms by which cancer cells cross the BBB. Different molecular, biochemical and immunofluorescent techniques will be applied to elucidate the role of various signaling mechanisms, proteolytic enzymes and brain derived factors in the interaction of metastasizing cancer cells with brain resident cells. In vivo, advanced microscopic techniques (two photon microscopy) will be applied to monitor the process of transmigration and metastatic colonization of the brain.
Required language skills: English B2 Number of students who can be accepted: 2
Deadline for application: 2018-09-26
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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