Thesis supervisor: Gábor Molnár
Location of studies (in Hungarian): University of Szeged, Department of Physiology, Anatomy and Neuroscience, Szeged, Közép fasor 52. Abbreviation of location of studies: SzTE
Description of the research topic:
What makes us human? This is a long debated question, and yet unknown how information is processed in our brain. To date research on the human cortex mainly performed by noninvasive approaches and properties of cortical microcircuits are yet to be uncovered.
In collaboration with the Department of Neurosurgery we found enhanced signal transmission between cells: it is faster and stronger then it was found in animal models (Molnár et al., 2008; Komlósi et al, 2012; Faragó et al. 2016; Molnár et al., 2016; Szegedi et al. 2016, Szegedi et al. 2017). Furthermore it has been unveiled that stronger synapses can have exclusive plasticity. This suggests that these distinct features might mediate the ability to perform highly complex cognitive tasks of the human neocortex. The aim of our project is to collect information about the microscale properties of human neurons e.g. features of excitatory transmission during synaptic depression, and intracellular signal propagation using state-of-the-art techniques (electrophysiology, molecular biology, electron microscopy, imaging techniques etc.). Therapies of neurodegenerations are based on animal models and manage only the symptoms. Our results, apart from deepening our understanding of basic features and mechanisms neuronal circuits and connections, can also provide a basis for development of proper therapies for neurodegenerations.
Required language skills: English B2 Further requirements: strong determination and meticulous working attitude
Number of students who can be accepted: 2
Deadline for application: 2018-09-26
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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