Thesis supervisor: Lajos Haracska
Location of studies (in Hungarian): Institute of Genetics, Biological Research Centre of the Hungarian Academy of Sciences Abbreviation of location of studies: SZBK
Description of the research topic:
To study genes that participate in maintaining genome stability, we employ Crisper/Cas9 and RNA-interference-based gene silencing and analyse the role of proteins affecting the speed of DNA replication, via special confocal microscopy, in the presence of different agents (tumour therapeutic drugs, DNA-damaging agents, replication inhibitors). We study DNA-damage tolerance and repair processes using special fluorescent labelling and microscopic techniques . We implement state-of-the-art technology (live-cell microscopy, single-cell qualitative and quantitative analyses) in our laboratory.
Our research tools include human tissue culture-based reporter systems, next-generation sequencing, and reconstituted in vivo systems using purified proteins. Our investigations will provide deeper insight into the molecular processes of genome instability and carcinogenesis, and by identifying new tumour markers and drug targets, we will be able to contribute to the prevention of resistance to tumortherapeutic drugs and the development of personalised tumour therapy.
Required language skills: English B2 Further requirements: A grade average above 4.0, participation at TDK or other competititons, lab experience.
Number of students who can be accepted: 1
Deadline for application: 2018-09-26
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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