Thesis supervisor: István Andó
co-supervisor: Gyöngyi Ilona Cinege
Location of studies (in Hungarian): Institute of Genetics, Biological Research Centre of the Hungarian Academy of Sciences Abbreviation of location of studies: SZBK
Description of the research topic:
The proposed project will identify regulatory mechanisms of the cell mediated immunity in the Drosophila melanogaster model organism. Our laboratory has generated molecular and genetic tools for the analysis of the Drosophila immune system and characterized the hemocyte subsets with respect to their tissue and lineage origin. We recently discovered a so far unidentified cell type, dubbed the multinucleated giant hemocyte, which is the functional homolog of the lamellocyte in Drosophila melanogaster and is similar to multinucleated giant cells, a characteristic for granulomas, a manifestation of chronic inflammation in vertebrates. Based on these findings we propose a project, with the aims of:
i) identifying and constructing novel molecular and genetic markers for further analysis of the immune system in Drosophila melanogaster and characterizing the identified novel molecules with respect to their function;
ii) performing a comparative gene expression profile analysis of hemocyte activation and differentiation in Drosophila melanogaster and selecting gene candidates for further analysis;
iii) finding vertebrate homologs of the newly identified molecules
Required language skills: English B2 Recommended language skills (in Hungarian): English Number of students who can be accepted: 1
Deadline for application: 2018-09-26
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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