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Thesis topic proposal
 
Cardiovascular effects of the modulation of the endocannabinoid system in rat models

THESIS TOPIC PROPOSAL

Institute: University of Szeged
biology
Doctoral School of Biology

Thesis supervisor: Anikó Pósa
co-supervisor: Renáta Szabó
Location of studies (in Hungarian): Department of Physiology, Anatomy and Neuroscience, Laboratory of Physiology and GLP Toxicology
Abbreviation of location of studies: SzTE


Description of the research topic:

The endocannabinoid system (ECS) has increasingly emerged as a key signaling system involved in all physiological and pathological functions. The ECS comprises the endocannabinoids, the enzymes involved in their biosynthesis and degradation, putative membrane transporters and the G-protein coupled receptors, including CB1 and CB2 receptors. CB1 receptor is predominantly expressed in the central nervous system, while the expression of CB2 receptors was thought to be limited to immune cells. However, these receptors have been recently identified in various peripheral tissues, including the myocardium, the coronary endothelial and smooth muscle cells, as well as the liver and the adipose tissue.
Therefore, activation or inhibition of CB receptors may offer therapeutic benefits against different cardiovascular and metabolic diseases.

Recommended language skills (in Hungarian): English
Number of students who can be accepted: 1

Deadline for application: 2018-09-26


2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).

 
All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )