Thesis supervisor: Csaba Vizler
Location of studies (in Hungarian): BRC of HAS, Szeged, Hungary Abbreviation of location of studies: SZBK
Description of the research topic:
The spread of antibiotic resistant pathogens and the prolongation of human life expectancy stress the importance of studies on the interaction of opportunistic pathogenic fungi and the mammalian immune system.
Based on our research experience obtained studying the immune response and our extensive knowledege of animal models, we will explore the pathogenesis of fungal infections. Our main research focus will be the dissection of immunomodulating activity of fungal strains. Our approach will be based on the use of tissue culture and experimental mouse models.
Thanks to our earlier collaborations, we have access to an array of natural and synthetic drug candidates that we intend to test in the models set up during the project.
References:
Csonka K, Vadovics M, Marton A, Vágvölgyi C, Zajta E, Tóth A, Tóth R, Vizler C, Tiszlavicz, Mora-Montes HM, Gácser A. Intravenous infection model of Candida parapsilosis in newborn mice. Frontiers in Microbiology, 2017 Jun 30;8:1197.
Navarro-Arias MJ, Defosse TA, Dementhon K, Csonka K, Mellado-Mojica E, Dias Valério A, González-Hernández RJ, Courdavault V, Clastre M, Hernández NV, Pérez-García LA, Singh DK, Vizler C, Gacser A, Almeida RS, Noël T, López MG, Papon N, Mora Montes HM. Disruption of Protein Mannosylation Affects Candida guilliermondii Cell Wall, Immune Sensing, and Virulence. Frontiers in Microbiology, 2016 Dec 2;7:1951.
Pérez-García LA, Csonka K, Flores-Carreón A, Estrada E, Mellado-Mojica E, Németh T, López-Ramírez LA, Toth R, López MG, Vizler C, Marton A, Toth A, Nosanchuk JD, Gacser A, Mora Montes HM. Role of Protein Glycosylation in Candida parapsilosis Cell Wall Integrity and Host Interaction. Frontiers in Microbiology 2016 Mar 8;7:306.
Buzas K, Marton A, Vizler C, Gyukity-Sebestyen E, Harmati M, Nagy K, Zvara A, Katona R, Tubak V, Endresz V, Nemeth I, Olah J, Vigh L, Biro T, Kemeny L. Bacterial sepsis increases survival in metastatic melanoma: Clamydophila pneumoniae induces macrophage polarization and tumor regression. J. Invest. Dermatol. 2016 Apr;136(4):862-5.
Manczinger M, Bocsik A, Kocsis GF, Vörös A, Hegedűs Z, Ördögh L, Kondorosi É, Marton A, Vízler C, Tubak V, Deli M, Kemény L, Nagy I, Lakatos L The absence of N-acetyl-D-glucosamine causes attenuation of virulence of Candida albicans upon interaction with vaginal epithelial cells in vitro. Biomed Res Int 2015;2015:398045.
Gyorfy Z, Duda E, Vizler C. Interactions between LPS moieties and macrophage pattern recognition receptors. Vet Immunol Immunopathol. 2013 Mar 15;152(1-2):28-36.
Eder K, Vizler C, Kusz E, Karcagi I, Glavinas H, Balogh GE, Vigh L, Duda E, Gyorfy Z. The role of lipopolysaccharide moieties in macrophage response to Escherichia coli. Biochem Biophys Res Commun. 2009 Nov 6;389(1):46-51.
Required language skills: EU B2 equivalent, English Recommended language skills (in Hungarian): EU B2 equivalent, English Further requirements: Laboratory research experience, EU C1 equivalent English certificate, FELASA certificate are advantages.
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