Thesis supervisor: Csaba Pál
Location of studies (in Hungarian): Biological Research Centre Hungarian Academy of Sciences, Institute of Biochemistry, Synthetic and Systems Biology Unit, Csaba Pál Laboratory Abbreviation of location of studies: SZBK
Description of the research topic:
The rapid spread of microbial antibiotic resistance and the ineffectiveness of traditional antibiotics cause a growing challenge in drug development. Therefore, developing novel antibiotics is of critical importance.
Synthetic biological studies in pathogenic bacteria can rapidly analyze possible resistance processes and thereby allow us to consider and involve resistance-development during antimicrobial drug-design.
The project will apply high-throughput bacterial mutagenesis and computational protein-ligand interaction analysis to analyze mutational processes of drug-targets which can cause resistance to an experimental antibiotic. To circumvent these possible resistance processes, we will suggest chemical modifications with an aim to decrease the probability of resistance development.
The project will involve the latest approaches from synthetic biology, utilize state-of-the-art sequencing technologies and computational tools for protein-ligand interaction analyses.
Required language skills: English B2 Recommended language skills (in Hungarian): English B2 Further requirements: Background in chemistry, synthetic chemistry, computational protein-ligand interaction analysis, experimental skills in synthetic biology.
Number of students who can be accepted: 1
Deadline for application: 2018-09-26
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
Login
