Thesis supervisor: Áron Vincze
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigedti u. 12. Abbreviation of location of studies: ÁOK
Description of the research topic:
The aim of this research is to analyze the factors determining the diversity of celiac disease.
The diagnosis of celiac disease is sometimes challenging. In addition to the extraordinary variability in clinical presentation, severe intestinal and extraintestinal symptoms and accompanying diseases may develop. Some patients complain of typical gastrointestinal symptoms whereas others exhibit an atypical presentation. The phenotype is often complicated by the development of autoimmune diseases and celiac complications. It is not clear how factors determine the clinical phenotype. The degree of small intestinal damage does not provide a satisfactory explanation for a phenomenon describing that patients may suffer from severe malabsorption or be asymptomatic with total villous atrophy.
In this project, we focus on the clinical phenotype of celiac disease by approaching the diverse disease course from different aspects. We aim to answer the question how the genetic predisposition, especially the combination of HLA-DQ alleles, modifies the clinical phenotype. Concomitant diseases (especially the autoimmune diseases) and special subclinical alterations predisposing to higher complication rates, e.g., the association between hemorrheological parameters and the increased risk of thrombosis, are in the focus of interest.
Number of students who can be accepted: 1
Deadline for application: 2018-05-18
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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