Thesis supervisor: Kálmán Tóth
co-supervisor: István Battyáni
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12. Abbreviation of location of studies: ÁOK
Description of the research topic:
Develop and optimizing a nanocarrier platform which is suitable for targeted delivery of tPA and other potential thrombolytic drugs using iron oxide core. Developing an alternative protocol for synthetizing labeled nanoparticles to follow up the thrombus lysis at in vitro and in vivo environment Performing the sufficient physical-chemical characterizations such as measuring size, shape, Zeta-potential, stability, calculating the loaded amount of drug into the particles Testing the NPs in in vitro environment with and without flow. Developing a method for making identical thrombus (mouse, pig, human) in ex vivo environment Introducing the NPS into an alternative magnetic field for testing their behavior, measuring the lysis efficiency and time with heating effect. Developing a mouse and pig ferric chloride arterial injury model and testing the NPs in in vivo environment using intravital microscopy technique. Performing the remote guidance of NPs via external magnetic fields.
Number of students who can be accepted: 1
Deadline for application: 2018-05-18
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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