Thesis supervisor: István Szokodi
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12. Abbreviation of location of studies: ÁOK
Description of the research topic:
The development of cardiac remodeling is associated with fundamental changes in the molecular programs of the heart including the reactivation of fetal gene programs, deregulation of neurohormonal systems as well as the activation of senescence and various forms of cell death. It has long been considered that these gene programs are primarily under the control of protein-based regulatory systems (i.e. transcription factors and chromatin modifiers). It turned out that ~75% of the human genome is actively transcribed into RNA but only ~2% is translated into proteins. Understanding the functional significance of these non-coding RNA transcripts in versatile cellular processes is the subject of intense investigation. According to the most recent estimates, the human genome encodes for ~2000 different microRNAs and ~56000 long non-coding RNAs. Our main goal is to identify novel cell-type and context-specific interactions between, microRNAs, long non-coding RNAs, and mRNAs in regulating cardiac remodeling using the combination of in silico predictions, in vitro cell culture experiments, and animal models.
Number of students who can be accepted: 1
Deadline for application: 2018-05-18
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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