ODT - THESIS TOPIC: István Wittmann: Accumulation of hydroxyl free ...


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Thesis topic proposal

Accumulation of hydroxyl free radical products ortho- and meta- tyrosine is the cause of chronic hormone resistance

THESIS TOPIC PROPOSAL

Institute: University of Pécs
clinical medicine
Doctoral School of Clinical Medicine

Thesis supervisor: István Wittmann
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

As described in our patent ’Hormone resistance’, it has been discovered that accumulation of hydroxyl free radical products takes place in the blood vessel wall exposed to oxidative stress. These results are planned to be extended: we plan to investigate the insulin- and erythropoietin resistance developed in fat cells and the acetyl-choline resistance developed in the vessels due to the accumulation of ortho- and meta-tyrosine. We further plan to study the accumulation of abnormal tyrosine isoforms and their effects in renal failure.

Number of students who can be accepted: 1

Deadline for application: 2018-05-18

2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).