Thesis supervisor: Tamás Kőszegi
co-supervisor: István Bátai
Location of studies (in Hungarian): PTE ÁOK Szigeti u. 12. Abbreviation of location of studies: ÁOK
Description of the research topic:
Preconditioning means when the human body exerts a defense mechanism due to exposure of short-term ischemia or to low dose of chemical compounds in order to avoid further tissue injury. Early preconditioning results in the response of the body within a few minutes and it lasts for 3 hours. Effects of late preconditioning begin 8 hours later after exposure to provoking agents reaching the maximum effect at 24 h and the total duration is at about 96 h. Protective effect of ischemia is realized not only in local processes but it has a beneficial effect in distant organs that will be exposed later to ischemic events. This is called remote ischaemic preconditioning (RIP). Besides a large body of evidences (in vitro and animal models) human studies also support the protective effects of chemical preconditioning in heart and liver surgery. After pursuing in vitro and animal models preliminary studies in humans also support that anesthetic preconditioning reduces postoperative stress response. In the proposed project we plan to study the effects of early and late preconditioning in the surgical groups and also those of distant ischemic preconditioning groups by measuring oxidative stress markers and total antioxidant capacity with luminescent techniques. The obtained results will be compared to classical lab data that might have influence on antioxidant parameters and also with classical stress markers.
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