ODT - THESIS TOPIC: Krisztián Kvell: Establishment of personalised 3D ...


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Thesis topic proposal

Establishment of personalised 3D thymus from peripheral blood

THESIS TOPIC PROPOSAL

Institute: University of Pécs
theoretical medicine
Doctoral School of Basic Medicine

Thesis supervisor: Krisztián Kvell
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

Thymic aging begins early, accelerates with puberty and continues at an individual pace. If the thymus shows accelerated aging, its biological age is ahead of chronological age. Thymic aging may be accelerated by various factors including toxic substances, steroid hormones, infections. These can significantly decrease fresh naive T-cell output leading to increased incidence of infections, cancers and autoimmune diseases. Our long-term goal is to establish artificial personalised 3D thymus tissue from peripheral blood that is suitable for both immunology research and medical autologous reimplantation to support immune functions. For this first 3D PCL scaffold is printed then colonised by thymic epithelial cells trans-differentiated from peripheral blood monocytes. This is then seeded with peripheral blood hemopoetic stem cells (CD34+ HSC) differentiated towards T-lineage thus constructing a thymus lobe.

Number of students who can be accepted: 1

Deadline for application: 2018-05-18

2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).