ODT - THESIS TOPIC: Péter Balogh: Role of Nkx2-3 transcription ...

Role of Nkx2-3 transcription factor in the regulation of innate lymphoid cell homeostasis in visceral lymphoid organs and the onset of inflammatory bowel diseases

THESIS TOPIC PROPOSAL

Institute: University of Pécs
theoretical medicine
Doctoral School of Basic Medicine

Thesis supervisor: Péter Balogh
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

Lymphoid tissues formed in the intestines play important roles in the simultaneous defence against gut microbiota and establishment of tolerance towards the polysaccharide and protein components of food. In chronic inflammatory bowel diseases (IBD) induced by altered enteral microbes innate lymphoid cells (ILC) and innate-like lymphocytes (ILC) may have important contribution. Although IBD is frequently associated with enhanced expression of Nkx2-3 homeodomain transcription factor, currently there are no suitable in vivo experimental models which could be used to investigate its involvement in the homeostasis and mucosal function of ILL/ILC cells. The aim of this work is to clarify the role of Nkx2-3 in the (1) maturation of gut-associated lymphoid tissues, (2) splenic and intestinal homeostasis of ILC/ILL cells and (3) their recirculation using transgenic and chimera animal models, including cellular and molecular assay.

Number of students who can be accepted: 1

Deadline for application: 2018-05-18