ODT - THESIS TOPIC: Marianna Pap: Investigation of endoplasmic reticulum ...


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Thesis topic proposal

Investigation of endoplasmic reticulum stress in different tumor cell lines

THESIS TOPIC PROPOSAL

Institute: University of Pécs
theoretical medicine
Doctoral School of Interdisciplinary Medical Sciences

Thesis supervisor: Marianna Pap
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

The endoplasmic reticulum (ER) has an essential role in the synthesis, folding and processing of secretory proteins. The ER is armed with a quality control system to ensure that only properly folded proteins leave the ER lumen. Accumulation of the unfolded/misfolded proteins activates the unfolded protein response, which can lead to the apoptosis of the cell. ER stress has a role in the development of several diseases, including cancer. Its selective induction might be a promising target of the p53-negative tumors. We analyze the role and mechanism of ER stress and try to find drugs which can induce ER stress in different cancer cell lines.

Number of students who can be accepted: 1

Deadline for application: 2018-05-18

2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).