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Thesis topic proposal
 
Thermodynamic (differential scanning calorimetry, DSC) investigation of the intermediate states of ATP hydrolysis cycle (in rabbit psoas muscle)

THESIS TOPIC PROPOSAL

Institute: University of Pécs
theoretical medicine
Doctoral School of Interdisciplinary Medical Sciences

Thesis supervisor: Dénes Lőrinczy
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK


Description of the research topic:

Glycerinated psoas muscle fiber is a good biochemical and mechanical model of the intact muscle. The ATP-hydrolysis cycle runs on ms time scale, so we need a very rapid technics to investigate it. We can make a long-living intermediate states with the help of different phosphate analogues with life time which fits to the measuring time of other techniques (e.g.: EPR and DSC). This way we are able to investigate the molecular dynamic and thermal stability of these states for the better understanding of muscle function.

Number of students who can be accepted: 1

Deadline for application: 2018-05-18


2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).

 
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