Thesis supervisor: György ifj. Sétáló
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12. Abbreviation of location of studies: ÁOK
Description of the research topic:
Rat pheochromocytoma (PC12) cells don't require the presence of nerve growth factor (NGF) for their survival. Upon treatment with the peptide, however, they differentiate into a sympathetic neuron-like phenotype. The main transducer of the underlying signals is the extracellular signal-regulated kinase cascade. In the complete absence of trophic support the cells die by apoptosis. Our goal is a better characterization of these signaling processes. Our experiments are carried out using immunoblots and confocal laser scanning fluorescence microscopy.