Thesis supervisor: György ifj. Sétáló
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12. Abbreviation of location of studies: ÁOK
Description of the research topic:
The project aims at the better understanding of intracellular signaling by polypeptide growth factors in a rat pheochromocytoma (PC12) model system. These cells undergo neuronal differentiation in the presence of nerve- and fibroblast growth factor (NGF and FGF, respectively). At the same time they respond with increased proliferation to epidermal growth factor (EGF) treatment. We investigate various components of signaling cascades during the cellular response, with special attention to molecular chaperones as part of the regulatory mechanisms. Immunological techniques like Western blot, immunoprecipitation and immunocytochemistry are used in wild type and mutant cell variants.