ODT - THESIS TOPIC: Pál Perjési: Structure-to-activity relationship studies on ...


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Thesis topic proposal

Structure-to-activity relationship studies on cytotoxic and cytoprotective effects of chalcones and chalcone analogues

THESIS TOPIC PROPOSAL

Institute: University of Pécs
pharmaceutics
Doctoral School of Pharmacologycal and Pharmaceutical Sciences

Thesis supervisor: Pál Perjési
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

In our earlier studies several chalcone and cyclic chalcone analogues showed cancer cell cytotoxic effect. On the other hand, they showed structure-dependent antioxidant (cytoprotective) effect as well. Among the investigated compounds it was the seven-membered ring derivatives that showed the most promising effects. In the framework of the present program the aim of our study is to analyze how the steric, electronic and hydrophobic properties of the compounds affect their cytotoxic and cytoprotective activities. For determination of the relevant physico-chemical properties chromatographic and spectroscopic methods are applied. The antiproliferative effects are tested on different cell cultures.

Number of students who can be accepted: 1

Deadline for application: 2018-05-18

2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).