ODT - THESIS TOPIC: Pál Perjési: The role of glutathione-conjugation ...


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Thesis topic proposal

The role of glutathione-conjugation in the biologic effects of chalcones and chalcone analogues

THESIS TOPIC PROPOSAL

Institute: University of Pécs
pharmaceutics
Doctoral School of Pharmacologycal and Pharmaceutical Sciences

Thesis supervisor: Pál Perjési
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

In our earlier studies several chalcone and cyclic chalcone analogues showed cancer cell cytotoxic effect. On the other hand, they showed structure-dependent antioxidant (cytoprotective) effect as well. Cytotoxic effect of related α,β-unsaturated carbonyl compounds are frequently associated with their expected reactivity with the essential thiol groups in the living organisms Earlier results indicated that the investigated chalcones can react with reduced glutathione (GSH) even in spontaneous reaction. In the framework of the present program we are planning to investigate the kinetics and stereochemistry of the addition reactions by UV-Vis and HPLC methods. The kinetics of formation and the diasteromeric ratio of the chalcone-GSH adducts will be studied in the presence of GST enzyme as well.

Number of students who can be accepted: 1

Deadline for application: 2018-05-18

2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).