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Thesis topic proposal
 
Investigation of the mediators of systemic inflammation in different animal models

THESIS TOPIC PROPOSAL

Institute: University of Pécs
pharmaceutics
Doctoral School of Pharmacologycal and Pharmaceutical Sciences

Thesis supervisor: András Garami
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK


Description of the research topic:

Systemic inflammation constitutes a serious financial and healthcare problem even in the modern societies. Its on-target, efficient treatment would require the understanding of the involved neural, humoral, and endocrine regulatory factors as well as the effect of those factors on the progress of the disease. In small animals, systemic inflammation can be modeled in several different ways, for example with the administration of bacterial endotoxin, which evokes “aseptic” systemic inflammatory response syndrome (accompanied by fever or hypothermia) or with cecal ligature and puncture, which results in septic shock. Our goal is to investigate the role of certain receptors, neurotransmitters, humoral factors, and neural structures under the formerly mentioned and related inflammatory conditions. Our studies involve the measurement of body temperature in systemic inflammation models, as well as other in-vivo experiments (e.g., nociceptive tests), molecular biology, immunohistochemistry, and further experimental techniques.

Number of students who can be accepted: 1

Deadline for application: 2018-05-18


2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).

 
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