Thesis supervisor: Mária Anna Deli
Location of studies (in Hungarian): Institute of Biophysics, Biological Research Centre, Hungarian Academy of Sciences Abbreviation of location of studies: SZBK
Description of the research topic:
Brain capillaries, which form the anatomical basis of the blood-brain barrier, participate in the maintenance of the homeostasis of the nervous system by their influx transporters and physical and chemical defense systems. Solute carriers and and other transporters of cerebral endothelial cells carry nutrients from the blood to the brain, while active efflux pumps block the entry of toxic molecules present in the blood. The defense systems of the blood-brain barrier are damaged in several systemic and neuronal pathologies, like acute pancreatitis, epilepsy or neurodegenerative diseases. In these pathological conditions the function of the transporter and efflux pumps is damaged andf the permeability of the blood-brain barrier is increased. The dysfunction of the blood-brain barrier contributes to further neuronal loss and the aggravation of the diseases. Recently, the blood-brain barrier was identified as as a potential new therapeutic target. In our research group the effects of pathological factors damaging the blood-brain barrier and potential protective molecules are investigated on culture models of the blood-brain barrier.
Required language skills: English Further requirements: experience in cell culture and cell biology techniques
Number of students who can be accepted: 1
Deadline for application: 2018-02-28
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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