Thesis supervisor: Tamás Fehér
Location of studies (in Hungarian): The Institute of Biochemistry, Biological Research Center Abbreviation of location of studies: SzBK
Description of the research topic:
Transposable elements (TEs) are DNA segments that can move from one locus to the other within a genome. They are usually considered molecular parasites, but can, in certain cases provide benefits to their hosts. We have recently demonstrated that the advantage of a single copy of TE conferred to the host Escherichia coli cell is measurable under certain conditions. The projected work will probe the upper limits of TE copy numbers within bacteria, and its dependence on environmental factors and the genetic content of TEs. The forces of positive and negative selection, as well as the effect of regulation will be investigated. The obtained results will be immediately used for biotechnological purposes: the activity and the copy number of TEs will be controlled to modulate genomic stability of bacterial cell factories. Furthermore, novel genetic tools will be developed that rely on the controlled mobilization of TEs. The utility of these tools will be demonstrated in metabolic engineering projects aiming to produce added-value compounds in E. coli cells.
Required language skills: English Further requirements: basic molecular biology techniques
Number of students who can be accepted: 1
Deadline for application: 2018-02-28
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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