Thesis supervisor: László Somsák
Location of studies (in Hungarian): DE TTKSzerves Kémiai Tanszék E 422 Abbreviation of location of studies: E 422
Description of the research topic:
The C-glycosyl compounds exhibit a wide range of interesting biological effects, play important roles in the formation of hydrolitically stable carbohydrate derivatives as glycomimetics, and are the active ingredients of several recent antidiabetic medications. C-Glycosyl heterocycles with five-membered rings have extensively been studied as to their syntheses and biological activities. On the other hand, similar derivatives of six-membered heterocycles and especially their C-glycopyranosyl counterparts are very scarcely known in the literature among others due to the lack of suitable precursors.
This PhD project has a dual aim: a) based on precursors synthesized recently in our group, elaboration of the synthesis of nitrogen heterocycles with 1-4 heteroatoms; b) study of the possibilities for interconversion of the a forementioned heterocycles.
Under aim a) imidate, amidine and amidrazone type derivatives of anhydro-aldonic acids will be investigated to reveal the applicable protecting groups in their transformations to the target heterocycles, while under aim b) the inverse-electron demand Diels-Alder reactions of triazines and tetrazines towards pyridines and pyridazines will be studied.
Required language skills: angol Number of students who can be accepted: 2
Deadline for application: 2018-02-16
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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