Thesis supervisor: Levente Gellért
Location of studies (in Hungarian): Department of Physiology, Anatomy and Neuroscience, University of Szeged Közép fasor 52., Szeged, 6727 Abbreviation of location of studies: SzTE
Description of the research topic:
The causal role of diversion of the triptophan degradation through the kynurenin pathway has been described in several neurodegenerative and neuropsychiatric disorders (e.g. Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, cerebral ischemia, depression, schizophrenia). As a result, kynurenergic manipulation with the aim of therapy has been proposed recently. The multifaceted role of kynurenine metabolites in the central nervous system is researched intensively, however, the spatio-temporal expression pattern of the main enzymes involved in the catabolism has not been characterized, nor are important in vivo and in vitro models are described.. For a better understanding of the role of kynurenines (especially kynurenic acid-KYNA) in the brain, that is for appointing new therapeutic targets and for forecasting the possible adverse side effects of kynurenergic manipulations, the following are of particular importance: one, mapping the expression pattern of the main enzymes of kynurenine catabolism; andtwo, investigating the effect of pharmacological diversion of the pathway.
Required language skills: English, medium level Further requirements: Strong interest in neuroscience, ample knowledge in one of the following techniques: immunohistochemistry, behavioral assessments, electrophysiology
Number of students who can be accepted: 1
Deadline for application: 2017-09-27
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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