Thesis supervisor: Lajos Haracska
Location of studies (in Hungarian): Institute of Genetics, Biological Research Centre, HAS Szeged, Temesvári krt. 62. H-6726 Abbreviation of location of studies: SZBK
Description of the research topic:
In cells, DNA is damaged by several endogenous and exogenous factors. If the damage is not repaired, the replication machinery stalls during DNA doubling. Different mechanisms have evolved to rescue stalled replication forks; these help replication proceed over damaged DNA in an error-free or error-prone way. Error-prone processes, which cause mutations, increase the risk of carcinogenesis, while error-free replication protects genome stability and thus fulfils a tumour suppressor function.
Our research group investigates the causes and mechanisms of mutagenesis and carcinogenesis and strives to answer the questions of what the common roots of evolution and carcinogenesis are and how point mutations and chromosome rearrangements are generated. We also study the phenomenon of enhanced genome instability during tumorigenesis, the molecular role of recently described DNA repair genes in tumour suppression, and predisposition to tumorigenesis caused by certain mutations.
Our research tools include human tissue culture-based reporter systems, next-generation sequencing, and reconstituted in vivo systems using purified proteins. Our investigations will provide deeper insight into the molecular processes of genome instability and carcinogenesis, and by identifying new tumour markers and drug targets, we will be able to contribute to the development of personalised tumour therapy.
Required language skills: English Recommended language skills (in Hungarian): English Further requirements: a grade average above 4.0, participation at TDK or other competititons, lab experience
Number of students who can be accepted: 5
Deadline for application: 2017-09-27
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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