Thesis supervisor: Mária Anna Deli
Location of studies (in Hungarian): Institute of Biophysics, BRC, HAS Abbreviation of location of studies: SzBK
Description of the research topic:
The prediction of CNS drug distribution in humans is still a challenge in drug discovery and development. Recent advencements in cell culture and microfluidic chip techniques make it possible to develop more complex models to better mimic the barriers of the CNS. The aim of the project is to establish and characterize new models of the CNS barriers using a recently developed lab-on-a-chip device in BRC HAS (Walter et al. 2014). During the project the following major tasks will be completed:
(i) Establishment and characterization of double and triple co-culture models (endothelial cells, pericytes, astrocytes) of the blood-brain barrier (BBB) using a custom integrated microelectronic device (BBB on a chip).
(ii) Studying the effect of flow on rat and human co‐culture BBB models.
(iii) Employing double co-culture models (human stem cell derived endothelial and porcine or human choroid plexus epithelial cell lines) within the custom integrated microelectronic device to study the effect of co-culture in the absence or presence of flow on blood-cerebrospinal fluid barrier properties.
The project will be implemented in the frame of the Brain Barriers Training (BtRAIN) European Ph.D. Training Network (H2020-MSCA-ITN-2015 675619).
Required language skills: English Further requirements: experience in cell culture techniques
Number of students who can be accepted: 1
Deadline for application: 2017-01-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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