Thesis topic proposal
Gábor Szabó
The effect of epigenetic modifications and DNA superhelical density on nucleosome stability


Institute: University of Debrecen
theoretical medicine
Doctoral School of Molecular Cellular and Immune Biology

Thesis supervisor: Gábor Szabó
Location of studies (in Hungarian): Debreceni Egyetem, Általános Orvostudományi Kar
Abbreviation of location of studies: DEÁOK

Description of the research topic:

The repressive nature of nucleosomal structure predicts nucleosome eviction as a primary mechanism of gene regulation. Since DNA assumes a superhelical structure upon winding around the nuceosomes, changes of superhelical density can also influence the interaction between the histones and the DNA. These mutual interactions will be studied in permeabilized cell systems by confocal microscopy and laser scanning cytometry.

Number of students who can be accepted: 1

Deadline for application: 2017-01-15

All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )