Thesis supervisor: Dóra Zelena
Location of studies (in Hungarian): PTE ÁOK Abbreviation of location of studies: ÁOK
Description of the research topic:
In a triple transgenic mouse model of Alzheimer’s disease, we plan to map the development of comorbid anxiety depression. According to the literature, disease-specific brain lesions appear in 6-month-old mice, so a comparison of 4- and 8-month-old animals is planned. In parallel with extensive behavioral analyzes, we also plan to monitor the development of stress hormone levels, as depression is particularly characterized by increased stress activity, which is not sensitive to negative feedback from the effector molecule (e.g. glucocorticoids).
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