ODT - THESIS TOPIC: Zsuzsanna Helyes: Investigating the mechanisms of ...


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Thesis topic proposal

Investigating the mechanisms of Complex Regional Pain Syndrome in a mouse model

THESIS TOPIC PROPOSAL

Institute: University of Pécs
theoretical medicine
Doctoral School of Pharmacologycal and Pharmaceutical Sciences

Thesis supervisor: Zsuzsanna Helyes
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

Enhanced inflammation and hyperalgesia are induced in mice with passive transfer (i.p. injection) of the IgG fraction of Complex Regional Pain Syndrome (CRPS) patients after a minor injury. In this model developed, published and validated by us, we focus on the peripheral and central sensitization mechanisms with special emphasis on the role of sensory-immune interactions, neuropeptides, cytokines, as well as glia cell activation. Our results can help to identify the key mediators and targets in this disease that can open novel perspectives for drug development.

Number of students who can be accepted: 1

Deadline for application: 2023-05-17