Thesis topic proposal
Lóránd Kelemen
Cell-cell interaction studied with optical tweezers


Institute: University of Szeged
theoretical medicine
Doctoral School of Multidisciplinary Medical Scienses

Thesis supervisor: Lóránd Kelemen
Web address (URL): https://brc.hu/biophys_optical_micromanipulation.php
Location of studies (in Hungarian): Institute of Biophysics - Bionanoscience Research Unit - Optical Micromanipulation Research Group
Abbreviation of location of studies: SZBK

Description of the research topic:

The use of laser tweezer or optical tweezer is getting widespread in single cell studies. It provides a non-invasive tool for the manipulation or actuiation of the cells or for initiating interaction between cells or cells and artificial micrometer-sized objects. Its advanced version, that uses multiple trapping points is called holographic optical tweezers; it can be used, for instance to trap and actuate artifdicial 3D micro objects with 6 degrees of freedom. When a cell is attached to such an optically manipulated object, the actuation of the cell can be achieved without its irradiation damage with the very intense focused trapping laser beam. The research focuses on the interaction between two of such indirectly trapped cells or between a trapped cell and a cultured cell layer. The advantages of the method are the exact timing of the interaction, multi-view fluorescence observation, the possibility to measure interaction forces and to initiate interaction between cells with any desired orientation.

Required language skills: English
Further requirements: 
TDK munka

Number of students who can be accepted: 1

Deadline for application: 2023-06-12

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