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Thesis topic proposal
 
Szilvia Veszelka
Mária Anna Deli
Examination of nanoparticles in cell culture models of blood-brain barrier

THESIS TOPIC PROPOSAL

Institute: University of Szeged
biology
Doctoral School of Biology

Thesis supervisor: Mária Anna Deli
co-supervisor: Szilvia Veszelka
Location of studies (in Hungarian): University of Szeged, Faculty of Science and Informatics, Department of Biochemistry and Molecular Biology
Abbreviation of location of studies: SZTE


Description of the research topic:

Pharmaceutical treatment of most disorders of the central nervous system (CNS), like neurodegenerative diseases or brain tumors, is far from satisfactory due to the poor penetration of drugs to the brain. Most pharmaceutical drug candidates have a low permeability across the blood-brain barrier. Colloidal drug targeting systems, so-called nanocarriers hold the greatest promise for future clinical application. The aim of our research to design and investigate different biodegradable and biocompatible nanoparticles which can encapsulate hydrophilic or lipophilic therapeutic agents. Targeting nanoparticles with different ligands of nutrient transporters present at the blood-brain barrier can increase the efficacy of drug transport to the brain.

Required language skills: English
Number of students who can be accepted: 1

Deadline for application: 2020-09-25

 
All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )