Thesis topic proposal
Imola Wilhelm
Role of the blood-brain barrier in the formation of brain metastases


Institute: University of Szeged
theoretical medicine
Theoretical Medicine Doctoral School

Thesis supervisor: Imola Wilhelm
Location of studies (in Hungarian): MTA SZBK Biofizikai Intézet
Abbreviation of location of studies: SZBK

Description of the research topic:

Metastases of the central nervous system – the majority of which originate from lung cancer, breast cancer (mainly the triple negative form) and melanoma – are life threatening pathologies with limited therapeutic options. Tumor cells invading the brain parenchyma have to extravasate through the blood-brain barrier and to survive in the hostile brain microenvironment. By using in vitro and in vivo models, the project is focused on the elucidation of the molecular mechanisms of brain metastasis formation. Different molecular biology, biochemical and advanced microscopy (confocal, two-photon and superresolution) techniques will be applied to elucidate the role of various signaling mechanisms, proteolytic enzymes and brain-derived factors in the interaction between host cells and metastasizing cancer cells.

Required language skills: english

Deadline for application: 2019-12-31

All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )