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Thesis topic proposal
 
Csaba Tömböly
Synthesis and in vitro pharmacological characterization of bifunctional MOP – CB1 receptor ligands

THESIS TOPIC PROPOSAL

Institute: University of Szeged
theoretical medicine
Theoretical Medicine Doctoral School

Thesis supervisor: Csaba Tömböly
Location of studies (in Hungarian): Laboratory of Chemical Biology, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences
Abbreviation of location of studies: BRC


Description of the research topic:

The interaction of G-protein coupled receptors (GPCR) is a well-documented phenomenon that can result in modified signaling. Bifunctional ligands can be able to interact with GPCR monomers and/or dimers as well in a synergistic manner. The mu opioid receptors (MOR) and the cannabinoid (CB) receptors are important pharmacological targets in pain management, their co-localization and interaction are experimentally evidenced. The responsibility of the candidate is to develop novel ligands for the activation of MOR and CB receptors followed by pharmacological characterization of the bifunctional compounds.

Required language skills: english
Number of students who can be accepted: 1

Deadline for application: 2019-12-31

 
All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )