Thesis topic proposal
Lóránd Kiss
Zoltán ifj Rakonczay
Investigating the effect of organosulfur molecules on the severity of experimental acute pancreatitis


Institute: University of Szeged
theoretical medicine
Theoretical Medicine Doctoral School

Thesis supervisor: Zoltán ifj Rakonczay
co-supervisor: Lóránd Kiss
Location of studies (in Hungarian): University of Szeged, Faculty of Medicine Department of Pathophysiology
Abbreviation of location of studies: KÓRÉL

Description of the research topic:

Acute pancreatitis is a sudden inflammation of the pancreas. In 15-20% of cases, patients show moderate to severe condition with local and systemic complications including organ failure and sepsis. There are supportive therapies, but no specific treatment against it. Previous investigations have demonstrated that hydrogen sulfide and organosulfur molecules are biologically active and have anti-inflammatory properties. Dimethyl trisulfide and diallyl trisulfide, belong to organic sulfide molecules. They have analgesic effects and are protective in several disorders. Our aims are to investigate whether the above-mentioned organosulfur molecules could alleviate the severity of experimental acute pancreatitis and to reveal their mechanism of action.

Required language skills: english
Number of students who can be accepted: 1

Deadline for application: 2019-12-31

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