ODT - THESIS TOPIC: Mária Anna Deli: Analysis of blood-brain barrier ...


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Thesis topic proposal

Analysis of blood-brain barrier characteristics in inflammatory conditions using animal models and endothelial cell cultures

THESIS TOPIC PROPOSAL

Institute: University of Szeged
theoretical medicine
Theoretical Medicine Doctoral School

Thesis supervisor: Mária Anna Deli
co-supervisor: Zsófia Hoyk
Location of studies (in Hungarian): SZBK Biofizikai Intézet
Abbreviation of location of studies: SZBK

Description of the research topic:

The blood-brain barrier (BBB) is a dynamic interface between the circulating blood and the brain parenchyma. The BBB is formed by endothelial cells that interact with pericytes and astroglial endfeet surrounding brain capillaries. BBB dysfunction is often observed in different pathological conditions, the common feature of which is inflammation. Based on our previous results morphological characteristics of the BBB under inflammatory conditions will be analyzed in an animal model, and using an in vitro BBB model.

Required language skills: english
Number of students who can be accepted: 1

Deadline for application: 2019-12-31