Thesis supervisor: Imola Csilla Szigyártó
Location of studies (in Hungarian): Research Centre for Natural Sciences of Hungarian Academy of Sciences Abbreviation of location of studies: MTA
Description of the research topic:
Extracellular vesicles (EVs) are biological nanoparticles released by cells into the extracellular space and contain biomolecules (such as DNA, RNA, proteins, phospholipids) that may be characteristic to their cell of origin. They are important mediators of intracellular communication and are involved in many physiological conditions, so they may provide a wealth of information for early diagnosis and treatment of various diseases. With the growing interest in EVs, various isolation techniques have been developed. The efficiency of isolation using density-and size-based isolation methods will be compared. Different bio-physical characterization methods will be used including electron microscopy, dynamic light scattering, protein assays, and spectroscopy methods. In addition, vesicles interactions with drug molecules will be investigated.
Required language skills: English (at least B2 level) Further requirements: goog synthetic skill, wide interest in structure investigation/separation methods
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