Personal data sheet
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personal data approved: 2020. IX. 07.
Personal data
Attila Ambrus
name Attila Ambrus
name of institution
doctoral school
SE János Szentágothai Doctoral School of Neurosciences (Supervisor)
accreditation statement submitted to: Semmelweis University, Budapest
Contact details
phone number +36 1 459-1500/60050
own web page
Academic title
scientific degree, title Ph.D.
year degree was obtained 2001
discipline to which degree belongs theoretical medicine
institution granting the degree University of Debrecen
2006 - Semmelweis University, Budapest
other (not specified) (egyetemi docens)
Thesis topic supervisor
number of doctoral students supervised until now 4.5
number of students who fulfilled course requirements 3
students who obtained their degrees:
Réka Mizsei PhD 2021  JSDSN
Eszter Szabó PhD 2020  JSDSN

completed course requirement:
Bálint Nagy (PhD) 2018/08  JSDSN
present PhD students:
(50%) Éva Nemes-Nikodém (PhD) (2022/08)  JSDSN
Zsófia Melinda Zámbó (PhD) (2022/08)  JSDSN
  Thesis topic proposals
research area Investigation of molecular pathology of mitochondrial alpha-ketoglutarate dehydrogenase multienzyme complex and other dehydrogenase enzymes by modern biochemical, biophysical and structural methods.
research field in which current research is conducted theoretical medicine

Szabo Eszter, Wilk Piotr, Nagy Balint, Zambo Zsofia, Bui David, Weichsel Andrzej, Arjunan Palaniappa, Torocsik Beata, Hubert Agnes, Furey William, Montfort William R, Jordan Frank, Weiss Manfred S, Adam-Vizi Vera, Ambrus Attila: Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants, HUMAN MOLECULAR GENETICS In press: p. In press.
type of document: Journal paper/Article
language: English

Ambrus A, Adam-Vizi V: Human dihydrolipoamide dehydrogenase (E3) deficiency: Novel insights into the structural basis and molecular pathomechanism, NEUROCHEMISTRY INTERNATIONAL 117: pp. 5-14.
type of document: Journal paper/Review paper
number of independent citations: 6
language: English

Szabo E, Mizsei R, Wilk P, Zambo Z, Torocsik B, Weiss MS, Adam-Vizi V, Ambrus A: Crystal structures of the disease-causing D444V mutant and the relevant wild type human dihydrolipoamide dehydrogenase, FREE RADICAL BIOLOGY AND MEDICINE 124: pp. 214-220.
type of document: Journal paper/Article
language: English

Ambrus A, Wang J, Mizsei R, Zambo Z, Torocsik B, Jordan F, Adam-Vizi V: Structural alterations induced by ten disease-causing mutations of human dihydrolipoamide dehydrogenase analyzed by hydrogen/deuterium-exchange mass spectrometry: Implications for the structural basis of E3 deficiency, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1862: (11) pp. 2098-2109.
type of document: Journal paper/Article
number of independent citations: 2
language: English

Ambrus A, Nemeria NS, Torocsik B, Tretter L, Nilsson M, Jordan F, Adam-Vizi V: Formation of reactive oxygen species by human and bacterial pyruvate and 2- oxoglutarate dehydrogenase multienzyme complexes reconstituted from recombinant components, FREE RADICAL BIOLOGY AND MEDICINE 89: pp. 642-650.
type of document: Journal paper/Article
number of independent citations: 16
language: English

Ambrus A, Torocsik B, Tretter L, Ozohanics O, Adam-Vizi V: Stimulation of reactive oxygen species generation by disease-causing mutations of lipoamide dehydrogenase, HUMAN MOLECULAR GENETICS 20: (15) pp. 2984-2995.
type of document: Journal paper/Article
number of independent citations: 20
language: English

Ambrus A, Tretter L, Adam-Vizi V: Inhibition of the alpha-ketoglutarate dehydrogenase-mediated reactive oxygen species generation by lipoic acid., JOURNAL OF NEUROCHEMISTRY 109: (Suppl 1) pp. 222-229.
type of document: Journal paper/Konferenciaközlemény
number of independent citations: 22
language: English

Ambrus A, Chen D, Dai J, Bialis T, Jones RA, Yang D: Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution., NUCLEIC ACIDS RESEARCH 34: (9) pp. 2723-2735.
type of document: Journal paper/Article
number of independent citations: 708
language: English

Ambrus A, Chen D, Dai J X, Jones R A, Yang D Z: Solution structure of the biologically relevant g-quadruplex element in the human c-MYC promoter. implications for g-quadruplex stabilization, BIOCHEMISTRY 44: (6) pp. 2048-2058.
type of document: Journal paper/Article
number of independent citations: 310
language: English

Ambrus A, Bányai I, Weiss M S, Hilgenfeld R, Keresztessy Z, Muszbek L, Fésüs L: Calcium binding of transglutaminases: A Ca-43 NMR study combined with surface polarity analysis, JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS 19: (1) pp. 59-74.
type of document: Journal paper/Article
number of independent citations: 12
language: English
Number of independent citations to these publications:1096 
Scientometric data
list of publications and citations
number of scientific publications that meet accreditation criteria:
number of scientific publications:
monographs and professional books:
monographs/books in which chapters/sections were contributed:
scientific publications published abroad that meet the accreditation criteria:
publications not in Hungarian, published in Hungary, meeting the accreditation criteria:
number of independent citations to scientific publications and creative works:
further relevant information regarding accreditation (in Hungarian)
Bolyai Fellowship (2006-2009), Bolyai Plaquette (2010), Fulbright Fellowship (Rutgers University, 2012), EMBO Short-term Fellowship (University of Pittsburgh, 2011), The Protein Society Finn Wold Travel Award (2011), Bolyai Fellowship (2011-2014), Merit Prize (2016), Merit Prize (2019)

All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )