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personal data approved: 2023. IX. 08.
Personal data
Attila Ambrus
name Attila Ambrus
name of institution
doctoral school
SE János Szentágothai Doctoral School of Neurosciences (Academic staff member)
accreditation statement submitted to: Semmelweis University, Budapest
Contact details
phone number +36 1 459-1500/60050
own web page
Academic title
scientific degree, title Ph.D.
year degree was obtained 2001
discipline to which degree belongs theoretical medicine
institution granting the degree University of Debrecen
scientific degree, title DSc
year degree was obtained 2022
discipline to which degree belongs biology
institution granting the degree HAS
scientific degree, title Habilitation
year degree was obtained 2022
discipline to which degree belongs theoretical medicine
institution granting the degree Semmelweis University
Employment
2006 - Semmelweis University, Budapest
university professor or researcher
Thesis topic supervisor
number of doctoral students supervised until now 4.5
number of students who fulfilled course requirements 3
students who obtained their degrees:
Bálint Nagy PhD 2023  JSDSN
Réka Mizsei PhD 2021  JSDSN
Eszter Szabó PhD 2020  JSDSN

  Thesis topic proposals
Research
research area Investigation of molecular pathology of mitochondrial alpha-ketoglutarate dehydrogenase multienzyme complex and other dehydrogenase enzymes by modern biochemical, biophysical and structural methods.
research field in which current research is conducted theoretical medicine
biology
Publications
2023

Szabo E., Nemes-Nikodem E., Vass K.R., Zambo Z., Zrupko E., Torocsik B., Ozohanics O., Nagy B., Ambrus A.: Structural and Biochemical Investigation of Selected Pathogenic Mutants of the Human Dihydrolipoamide Dehydrogenase, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24: (13) 10826
type of document: Journal paper/Article
language: English
URL 
2021

Nagy Balint, Polak Martin, Ozohanics Oliver, Zambo Zsofia, Szabo Eszter, Hubert Agnes, Jordan Frank, Novaček Jiří, Adam-Vizi Vera, Ambrus Attila: Structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate dehydrogenase complex (hKGDHc) revealed by cryo-EM and cross-linking mass spectrometry, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1865: (6) 129889
type of document: Journal paper/Article
number of independent citations: 9
language: English
URL 
2019

Szabo Eszter, Wilk Piotr, Nagy Balint, Zambo Zsofia, Bui David, Weichsel Andrzej, Arjunan Palaniappa, Torocsik Beata, Hubert Agnes, Furey William, Montfort William R, Jordan Frank, Weiss Manfred S, Adam-Vizi Vera, Ambrus Attila: Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants, HUMAN MOLECULAR GENETICS 28: (20) pp. 3339-3354.
type of document: Journal paper/Article
number of independent citations: 12
language: English
URL 
2018

Ambrus A, Adam-Vizi V: Human dihydrolipoamide dehydrogenase (E3) deficiency: Novel insights into the structural basis and molecular pathomechanism, NEUROCHEMISTRY INTERNATIONAL 117: pp. 5-14.
type of document: Journal paper/Review paper
number of independent citations: 23
language: English
URL 
2018

Szabo E, Mizsei R, Wilk P, Zambo Z, Torocsik B, Weiss MS, Adam-Vizi V, Ambrus A: Crystal structures of the disease-causing D444V mutant and the relevant wild type human dihydrolipoamide dehydrogenase, FREE RADICAL BIOLOGY AND MEDICINE 124: pp. 214-220.
type of document: Journal paper/Article
number of independent citations: 5
language: English
URL 
2015

Ambrus A, Nemeria NS, Torocsik B, Tretter L, Nilsson M, Jordan F, Adam-Vizi V: Formation of reactive oxygen species by human and bacterial pyruvate and 2- oxoglutarate dehydrogenase multienzyme complexes reconstituted from recombinant components, FREE RADICAL BIOLOGY AND MEDICINE 89: pp. 642-650.
type of document: Journal paper/Article
number of independent citations: 28
language: English
URL 
2011

Ambrus A, Torocsik B, Tretter L, Ozohanics O, Adam-Vizi V: Stimulation of reactive oxygen species generation by disease-causing mutations of lipoamide dehydrogenase, HUMAN MOLECULAR GENETICS 20: (15) pp. 2984-2995.
type of document: Journal paper/Article
number of independent citations: 27
language: English
URL 
2009

Ambrus A, Tretter L, Adam-Vizi V: Inhibition of the alpha-ketoglutarate dehydrogenase-mediated reactive oxygen species generation by lipoic acid, JOURNAL OF NEUROCHEMISTRY 109: (Suppl. 1) pp. 222-229.
type of document: Journal paper/Article
number of independent citations: 33
language: English
URL 
2006

Ambrus A, Chen D, Dai J, Bialis T, Jones RA, Yang D: Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution., NUCLEIC ACIDS RESEARCH 34: (9) pp. 2723-2735.
type of document: Journal paper/Article
number of independent citations: 923
language: English
URL 
2005

Ambrus A, Chen D, Dai J X, Jones R A, Yang D Z: Solution structure of the biologically relevant g-quadruplex element in the human c-MYC promoter. implications for g-quadruplex stabilization, BIOCHEMISTRY 44: (6) pp. 2048-2058.
type of document: Journal paper/Article
number of independent citations: 463
language: English
URL 
Number of independent citations to these publications:1523 
Scientometric data
list of publications and citations
number of scientific publications that meet accreditation criteria:
62
number of scientific publications:
62
monographs and professional books:
0
monographs/books in which chapters/sections were contributed:
0 
scientific publications published abroad that meet the accreditation criteria:
56
publications not in Hungarian, published in Hungary, meeting the accreditation criteria:
2
number of independent citations to scientific publications and creative works:
2555
further relevant information regarding accreditation (in Hungarian)
Bolyai Fellowship (2006-2009), Bolyai Plaquette (2010), Fulbright Fellowship (Rutgers University, 2012), EMBO Short-term Fellowship (University of Pittsburgh, 2011), The Protein Society Finn Wold Travel Award (2011), Bolyai Fellowship (2011-2014), Merit Prize (2016), Merit Prize (2019), Merit Prize (2023)

 
All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )