Attila Ambrus - ODT Personal data sheet


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Personal data sheet

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personal data approved: 2019. XI. 05.

Personal data

name	Attila Ambrus
name of institution	Semmelweis University, Budapest
doctoral school	SE János Szentágothai Doctoral School of Neurosciences (Supervisor Az oktató valamelyik doktori iskolában egy vagy több doktorandusz vagy doktorjelölt munkáját irányítja. )
accreditation statement submitted to:	Semmelweis University, Budapest

Contact details
E-mail address	attila.ambruseok.sote.hu
phone number	+36 1 459-1500/60050
	own web page

Academic title
scientific degree, title	Ph.D.
year degree was obtained	2001
discipline to which degree belongs	theoretical medicine
institution granting the degree	University of Debrecen

Employment
2006 -	Semmelweis University, Budapest other (not specified) (egyetemi docens)

Thesis topic supervisor

number of doctoral students supervised until now

4.5

number of students who fulfilled course requirements

students who obtained their degrees:

completed course requirement, without degree or degree granting in process:

	Bálint Nagy	(PhD)	2018/08	JSDSN
	Eszter Szabó	(PhD)	2018/01	JSDSN

present PhD students:

(50%)	Éva Nemes-Nikodém	(PhD)	(2022/08)	JSDSN
	Réka Mizsei	(PhD)	(2021/08)	JSDSN
	Zsófia Melinda Zámbó	(PhD)	(2020/08)	JSDSN

Thesis topic proposals

Research
research area	Investigation of molecular pathology of mitochondrial alpha-ketoglutarate dehydrogenase multienzyme complex and other dehydrogenase enzymes by modern biochemical, biophysical and structural methods.
research field in which current research is conducted	theoretical medicine biology

Publications

2019

Szabo Eszter, Wilk Piotr, Nagy Balint, Zambo Zsofia, Bui David, Weichsel Andrzej, Arjunan Palaniappa, Torocsik Beata, Hubert Agnes, Furey William, Montfort William R, Jordan Frank, Weiss Manfred S, Adam-Vizi Vera, Ambrus Attila: Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants, HUMAN MOLECULAR GENETICS In press: p. In press.
type of document: Journal paper/Article
language: English
URL

2018

Ambrus A, Adam-Vizi V: Human dihydrolipoamide dehydrogenase (E3) deficiency: Novel insights into the structural basis and molecular pathomechanism, NEUROCHEMISTRY INTERNATIONAL 117: pp. 5-14.
type of document: Journal paper/Review paper
number of independent citations: 6
language: English
URL

2018

Szabo E, Mizsei R, Wilk P, Zambo Z, Torocsik B, Weiss MS, Adam-Vizi V, Ambrus A: Crystal structures of the disease-causing D444V mutant and the relevant wild type human dihydrolipoamide dehydrogenase, FREE RADICAL BIOLOGY AND MEDICINE 124: pp. 214-220.
type of document: Journal paper/Article
language: English
URL

2016

Ambrus A, Wang J, Mizsei R, Zambo Z, Torocsik B, Jordan F, Adam-Vizi V: Structural alterations induced by ten disease-causing mutations of human dihydrolipoamide dehydrogenase analyzed by hydrogen/deuterium-exchange mass spectrometry: Implications for the structural basis of E3 deficiency, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1862: (11) pp. 2098-2109.
type of document: Journal paper/Article
number of independent citations: 2
language: English
URL

2015

Ambrus A, Nemeria NS, Torocsik B, Tretter L, Nilsson M, Jordan F, Adam-Vizi V: Formation of reactive oxygen species by human and bacterial pyruvate and 2- oxoglutarate dehydrogenase multienzyme complexes reconstituted from recombinant components, FREE RADICAL BIOLOGY AND MEDICINE 89: pp. 642-650.
type of document: Journal paper/Article
number of independent citations: 16
language: English
URL

2011

Ambrus A, Torocsik B, Tretter L, Ozohanics O, Adam-Vizi V: Stimulation of reactive oxygen species generation by disease-causing mutations of lipoamide dehydrogenase, HUMAN MOLECULAR GENETICS 20: (15) pp. 2984-2995.
type of document: Journal paper/Article
number of independent citations: 20
language: English
URL

2009

Ambrus A, Tretter L, Adam-Vizi V: Inhibition of the alpha-ketoglutarate dehydrogenase-mediated reactive oxygen species generation by lipoic acid., JOURNAL OF NEUROCHEMISTRY 109: (Suppl 1) pp. 222-229.
type of document: Journal paper/Konferenciaközlemény
number of independent citations: 22
language: English
URL

2006

Ambrus A, Chen D, Dai J, Bialis T, Jones RA, Yang D: Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution., NUCLEIC ACIDS RESEARCH 34: (9) pp. 2723-2735.
type of document: Journal paper/Article
number of independent citations: 708
language: English
URL

2005

Ambrus A, Chen D, Dai J X, Jones R A, Yang D Z: Solution structure of the biologically relevant g-quadruplex element in the human c-MYC promoter. implications for g-quadruplex stabilization, BIOCHEMISTRY 44: (6) pp. 2048-2058.
type of document: Journal paper/Article
number of independent citations: 310
language: English
URL

2001

Ambrus A, Bányai I, Weiss M S, Hilgenfeld R, Keresztessy Z, Muszbek L, Fésüs L: Calcium binding of transglutaminases: A Ca-43 NMR study combined with surface polarity analysis, JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS 19: (1) pp. 59-74.
type of document: Journal paper/Article
number of independent citations: 12
language: English
URL

Number of independent citations to these publications:

1096

Scientometric data

list of publications and citations

number of scientific publications that meet accreditation criteria:

number of scientific publications:

monographs and professional books:

monographs/books in which chapters/sections were contributed:

scientific publications published abroad that meet the accreditation criteria:

publications not in Hungarian, published in Hungary, meeting the accreditation criteria:

number of independent citations to scientific publications and creative works:

1903

further relevant information regarding accreditation (in Hungarian)
Bolyai Fellowship (2006-2009), Bolyai Plaquette (2010), Fulbright Fellowship (Rutgers University, 2012), EMBO Short-term Fellowship (University of Pittsburgh, 2011), The Protein Society Finn Wold Travel Award (2011), Bolyai Fellowship (2011-2014), Merit Prize (2016), Merit Prize (2019)