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personal data approved: 2020. XI. 01.
Personal data
name Csilla Laczka
name of institution
doctoral school
ELTE Doctoral School of Biology (Supervisor)
SE Doctoral School of Molecular Medicine (Supervisor)
the share of work in the different doctoral schools. ELTE Doctoral School of Biology 50%
SE Doctoral School of Molecular Medicine 50%
accreditation statement submitted to: Eötvös Loránd University, Budapest
Contact details
E-mail address lozvegybiomembrane.hu
phone number +36 1 382-6789
own web page
Academic title
scientific degree, title Ph.D.
year degree was obtained 2003
discipline to which degree belongs biology
institution granting the degree Eötvös Loránd University os Sciences
Employment
2013 - Enzimológiai Intézet, TTK, MTA (research institute, not university)
other (not specified) (tudományos főmunkatárs)
Thesis topic supervisor
number of doctoral students supervised until now 5.5
number of students who fulfilled course requirements 4
students who obtained their degrees:
Izabel Patik PhD 2020  DSB-ELTE
(50%) Csilla Hegedüs PhD 2014  DSB-ELTE

completed course requirement:
Izabel Patik (PhD) 2017/08  DSB-ELTE
present PhD students:
Hana Kaci (PhD) (2024/08)  DSB-ELTE
Orsolya Ungvári (PhD) (2024/08)  DSB-ELTE
Virág Székely (PhD) (2022/08)  DSMM-SE
Réka Laczkó-Rigó (PhD) (2021/08)  DSB-ELTE
  Thesis topic proposals
Research
research area Investigation of the transport mechanism, structure-function relationship and regulation of ABC (ATP Binding Cassette) proteins and organic anion transporting polipeptides (OATP).
research field in which current research is conducted biology
Publications
2020

Bakos Eva, Nemet Orsolya, Patik Izabel, Kucsma Nora, Varady Gyorgy, Szakacs Gergely, Ozvegy-Laczka Csilla: A novel fluorescence-based functional assay for human OATP1A2 and OATP1C1 identifies interaction between third-generation P-gp inhibitors and OATP1A2, FEBS JOURNAL 287: (12) pp. 2468-2485.
type of document: Journal paper/Article
language: English
URL 
2020

Laczkó-Rigó Réka, Jójárt Rebeka, Mernyák Erzsébet, Bakos Éva, Tuerkova Alzbeta, Zdrazil Barbara, Özvegy-Laczka Csilla: Structural dissection of 13-epiestrones based on the interaction with human Organic anion-transporting polypeptide, OATP2B1., JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 200: 105652
type of document: Journal paper/Article
language: English
URL 
2020

Székely V., Patik I., Ungvári O., Telbisz Á., Szakács G., Bakos É., Özvegy-Laczka C.: Fluorescent probes for the dual investigation of MRP2 and OATP1B1 function and drug interactions, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 151: 105395
type of document: Journal paper/Article
language: English
URL 
2020

Mohos Violetta, Fliszár-Nyúl Eszter, Ungvári Orsolya, Bakos Éva, Kuffa Katalin, Bencsik Tímea, Zsidó Balázs Zoltán, Hetényi Csaba, Telbisz Ágnes, Özvegy-Laczka Csilla, Poór Miklós: Effects of chrysin and its major conjugated metabolites chrysin-7-sulfate and chrysin-7-glucuronide on cytochrome P450 enzymes, and on OATP, P-gp, BCRP and MRP2 transporters, DRUG METABOLISM AND DISPOSITION 48: (10) pp. 1064-1073.
type of document: Journal paper/Article
number of independent citations: 1
language: English
URL 
2020

Tupova L., Hirschmugl B., Sucha S., Pilarova V., Székely V., Bakos É., Novakova L., Özvegy-Laczka C., Wadsack C., Ceckova M.: Interplay of drug transporters P-glycoprotein (MDR1), MRP1, OATP1A2 and OATP1B3 in passage of maraviroc across human placenta, BIOMEDICINE & PHARMACOTHERAPY 129: 110506
type of document: Journal paper/Article
language: English
URL 
2020

Bakos É., Tusnády G.E., Német O., Patik I., Magyar C., Németh K., Kele P., Özvegy-Laczka C.: Synergistic transport of a fluorescent coumarin probe marks coumarins as pharmacological modulators of Organic anion-transporting polypeptide, OATP3A1, BIOCHEMICAL PHARMACOLOGY 182: (December 2020) 114250
type of document: Journal paper/Article
language: English
URL 
2018

Patik I, Szekely V, Nemet O, Szepesi A, Kucsma N, Varady G, Szakacs G, Bakos E, Ozvegy-Laczka C: Identification of novel cell-impermeant fluorescent substrates for testing the function and drug interaction of Organic Anion-Transporting Polypeptides, OATP1B1/1B3 and 2B1., SCIENTIFIC REPORTS 8: (1) 2630
type of document: Journal paper/Article
number of independent citations: 3
language: English
URL 
2017

Kovacsics D, Patik I, Ozvegy-Laczka C: The role of organic anion transporting polypeptides in drug absorption, distribution, excretion and drug-drug interactions., EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 13: (4) pp. 409-424.
type of document: Journal paper/Article
number of independent citations: 21
language: English
URL 
2008

Szakacs G, Varadi A, Ozvegy-Laczka C, Sarkadi B: The role of abc transporters in drug absorption, distribution, metabolism, excretion and toxicity (adme-tox), DRUG DISCOVERY TODAY 13: (9-10) pp. 379-393.
type of document: Journal paper/Review paper
number of independent citations: 302
language: English
URL 
2004

Ozvegy-Laczka C, Hegedus T, Varady G, Ujhelly O, Schuetz JD, Varadi A, Keri G, Orfi L, Nemet K, Sarkadi B: High-affinity interaction of tyrosine kinase inhibitors with the ABCG2multidrug transporter, MOLECULAR PHARMACOLOGY 65: (6) pp. 1485-1495.
type of document: Journal paper/Article
number of independent citations: 292
language: English
URL 
Number of independent citations to these publications:619 
Scientometric data
list of publications and citations
number of scientific publications that meet accreditation criteria:
53
number of scientific publications:
65
monographs and professional books:
0
monographs/books in which chapters/sections were contributed:
0 
number of independent citations to scientific publications and creative works:
2789
further relevant information regarding accreditation (in Hungarian)
Postdoctoral fellowship of OTKA 2003, The award of Qualitas Biologica Fund for Ph.D. thesis 2003, Bolyai János fellowship of the Hungarian Academy of Scinces 2004, Scientific Award by the Hungarian Academy of Sciences for Young Researchers 2005., Farkas Tibor award for young membrane researchers 2007., Award from L’Oreal-Unesco for Women in Science 2008., Publication award by Sigma-Aldrich Ltd. 2009.

 
All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )