Csilla Laczka - ODT Personal data sheet


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Personal data sheet

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personal data approved: 2022. XII. 11.

Personal data

name	Csilla Laczka
name of institution	Eötvös Loránd University, Budapest Semmelweis University, Budapest
doctoral school	ELTE Doctoral School of Biology (Supervisor Az oktató valamelyik doktori iskolában egy vagy több doktorandusz vagy doktorjelölt munkáját irányítja. ) SE Doctoral School of Molecular Medicine (Academic staff member Az oktató a doktori iskola doktoranduszai számára oktat tantárgyat, és/vagy a doktori iskola megszavazta, hogy doktoranduszok számára kutatási témát írjon ki. ) SE Doctoral School of University Semmelweis (Announcer of research topic Az adott oktató valamelyik doktori iskolában kiírt doktoranduszok számára kutatási témát, amire most jelentkezni is lehet, de még nincsen témavezetett doktorandusza. )
the share of work in the different doctoral schools.	ELTE Doctoral School of Biology 50% SE Doctoral School of University Semmelweis 50%
accreditation statement submitted to:	Eötvös Loránd University, Budapest

Contact details
phone number	+36 1 382-6789
	own web page

Academic title
scientific degree, title	Ph.D.
year degree was obtained	2003
discipline to which degree belongs	biology
institution granting the degree	Eötvös Loránd University os Sciences
scientific degree, title	DSc
year degree was obtained	2022
discipline to which degree belongs	biology
institution granting the degree	HAS

Employment
2013 -	Enzimológiai Intézet, TTK, MTA (research institute, not university) other (not specified) (tudományos főmunkatárs)

Thesis topic supervisor

number of doctoral students supervised until now

5.5

number of students who fulfilled course requirements

students who obtained their degrees:

	Réka Laczkó-Rigó	PhD	2022	DSB-ELTE
	Virág Székely	PhD	2021	DSMM-SE
	Izabel Patik	PhD	2020	DSB-ELTE
(50%)	Csilla Hegedüs	PhD	2014	DSB-ELTE

completed course requirement:

Réka Laczkó-Rigó

(PhD)

2021/08

DSB-ELTE

present PhD students:

	Hana Kaci	(PhD)	(2024/08)	DSB-ELTE
	Orsolya Ungvári	(PhD)	(2024/08)	DSB-ELTE

Thesis topic proposals

Research
research area	Investigation of the transport mechanism, structure-function relationship and regulation of ABC (ATP Binding Cassette) proteins and organic anion transporting polipeptides (OATP).
research field in which current research is conducted	biology

Publications

2021

Ungvári Orsolya, Király Laura, Bakos Éva, Özvegy‐Laczka Csilla: 8‐acetoxy‐trisulfopyrene as the first activatable fluorogenic probe for add‐and‐read assessment of Organic anion‐transporting polypeptides, OATP1B1, OATP1B3, and OATP2B1, FASEB JOURNAL 35: (9) e21863
type of document: Journal paper/Article
language: English
URL

2020

Bakos Eva, Nemet Orsolya, Patik Izabel, Kucsma Nora, Varady Gyorgy, Szakacs Gergely, Ozvegy-Laczka Csilla: A novel fluorescence-based functional assay for human OATP1A2 and OATP1C1 identifies interaction between third-generation P-gp inhibitors and OATP1A2, FEBS JOURNAL 287: (12) pp. 2468-2485.
type of document: Journal paper/Article
language: English
URL

2020

Laczkó-Rigó Réka, Jójárt Rebeka, Mernyák Erzsébet, Bakos Éva, Tuerkova Alzbeta, Zdrazil Barbara, Özvegy-Laczka Csilla: Structural dissection of 13-epiestrones based on the interaction with human Organic anion-transporting polypeptide, OATP2B1., JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 200: 105652
type of document: Journal paper/Article
language: English
URL

2020

Székely V., Patik I., Ungvári O., Telbisz Á., Szakács G., Bakos É., Özvegy-Laczka C.: Fluorescent probes for the dual investigation of MRP2 and OATP1B1 function and drug interactions, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 151: 105395
type of document: Journal paper/Article
number of independent citations: 1
language: English
URL

2020

Mohos Violetta, Fliszár-Nyúl Eszter, Ungvári Orsolya, Bakos Éva, Kuffa Katalin, Bencsik Tímea, Zsidó Balázs Zoltán, Hetényi Csaba, Telbisz Ágnes, Özvegy-Laczka Csilla, Poór Miklós: Effects of chrysin and its major conjugated metabolites chrysin-7-sulfate and chrysin-7-glucuronide on cytochrome P450 enzymes, and on OATP, P-gp, BCRP and MRP2 transporters, DRUG METABOLISM AND DISPOSITION 48: (10) pp. 1064-1073.
type of document: Journal paper/Article
number of independent citations: 8
language: English
URL

2020

Bakos É., Tusnády G.E., Német O., Patik I., Magyar C., Németh K., Kele P., Özvegy-Laczka C.: Synergistic transport of a fluorescent coumarin probe marks coumarins as pharmacological modulators of Organic anion-transporting polypeptide, OATP3A1, BIOCHEMICAL PHARMACOLOGY 182: 114250
type of document: Journal paper/Article
number of independent citations: 1
language: English
URL

2018

Patik I, Szekely V, Nemet O, Szepesi A, Kucsma N, Varady G, Szakacs G, Bakos E, Ozvegy-Laczka C: Identification of novel cell-impermeant fluorescent substrates for testing the function and drug interaction of Organic Anion-Transporting Polypeptides, OATP1B1/1B3 and 2B1., SCIENTIFIC REPORTS 8: (1) 2630
type of document: Journal paper/Article
number of independent citations: 6
language: English
URL

2017

Kovacsics D, Patik I, Ozvegy-Laczka C: The role of organic anion transporting polypeptides in drug absorption, distribution, excretion and drug-drug interactions., EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 13: (4) pp. 409-424.
type of document: Journal paper/Article
number of independent citations: 25
language: English
URL

2008

Szakacs G, Varadi A, Ozvegy-Laczka C, Sarkadi B: The role of abc transporters in drug absorption, distribution, metabolism, excretion and toxicity (adme-tox), DRUG DISCOVERY TODAY 13: (9-10) pp. 379-393.
type of document: Journal paper/Review paper
number of independent citations: 321
language: English
URL

2004

Ozvegy-Laczka C, Hegedus T, Varady G, Ujhelly O, Schuetz JD, Varadi A, Keri G, Orfi L, Nemet K, Sarkadi B: High-affinity interaction of tyrosine kinase inhibitors with the ABCG2multidrug transporter, MOLECULAR PHARMACOLOGY 65: (6) pp. 1485-1495.
type of document: Journal paper/Article
number of independent citations: 300
language: English
URL

Number of independent citations to these publications:

662

Scientometric data

list of publications and citations

number of scientific publications that meet accreditation criteria:

number of scientific publications:

monographs and professional books:

monographs/books in which chapters/sections were contributed:

number of independent citations to scientific publications and creative works:

3442

further relevant information regarding accreditation (in Hungarian)

Postdoctoral fellowship of OTKA 2003, The award of Qualitas Biologica Fund for Ph.D. thesis 2003, Bolyai János fellowship of the Hungarian Academy of Scinces 2004, Scientific Award by the Hungarian Academy of Sciences for Young Researchers 2005., Farkas Tibor award for young membrane researchers 2007., Award from L’Oreal-Unesco for Women in Science 2008., Publication award by Sigma-Aldrich Ltd. 2009.

2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).