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personal data approved: 2019. VI. 13.
Personal data
László Őrfi
name László Őrfi
name of institution
doctoral school
BME George A. Olah Doctoral School of Chemistry and Chemical Technology (Academic staff member)
(discipline) Habilitation Comittee and Doctoral Council (external member)
SE Doctoral School of Pharmaceutical Sciences (Supervisor)
SE Doctoral School of Molecular Medicine (Announcer of research topic)
the share of work in the different doctoral schools. BME George A. Olah Doctoral School of Chemistry and Chemical Technology 10%
SE Doctoral School of Pharmaceutical Sciences 60%
SE Doctoral School of Molecular Medicine 10%
BME GAODSCC (discipline) Habilitation Comittee and Doctoral Council (external member) 20%
accreditation statement submitted to: Semmelweis University, Budapest
Contact details
phone number +36 1 217-0891
own web page
Academic title
scientific degree, title Ph.D.
year degree was obtained 1997
discipline to which degree belongs chemistry
institution granting the degree Semmelweis University
scientific degree, title Habilitation
year degree was obtained 2013
discipline to which degree belongs pharmaceutics
institution granting the degree Semmelweis University
Employment
1982 - Semmelweis University, Budapest
university professor or researcher
Thesis topic supervisor
number of doctoral students supervised until now 10
number of students who fulfilled course requirements 8
students who obtained their degrees:
Rita Garamvölgyi PhD 2017  DSPS1-SE
Ferenc Baska PhD 2015  DSPS1-SE
Gábor Németh PhD 2012  
Gábor Péter Bánhegyi PhD 2009  DSPS1-SE
Csaba Szántai-Kis PhD 2008  

completed course requirement, without degree or degree granting in process:
Anna Sipos (PhD) 2014/08  DSPS1-SE
Zoltán Nemes (PhD) 2015/08  DSPS1-SE
Zsófia Czudor (PhD) 2018/08  DSPS1-SE
present PhD students:
Marcell Krekó (PhD) (2022/08)  DSPS1-SE
Mihály Szabó (PhD) (2020/08)  DSPS1-SE
  Thesis topic proposals
Research
research area Pharmaceutical chemistry, kinase inhibitors, quantitative structure-activity relationship (QSAR, ADMET), drug design, lead optimisation, drug discovery, medicinal chemistry, paralell synthesis
research field in which current research is conducted pharmaceutics
chemistry
Publications
2018

Zsófia Czudor, Mária Balogh, Péter Bánhegyi, Sándor Boros, Nóra Breza, Judit Dobos, Márk Fábián, Zoltán Horváth, Eszter Illyés, Péter Markó, Anna Sipos, Csaba Szántai-Kis, Bálint Szokol, László Őrfi: Novel compounds with potent CDK9 inhibitory activity for the treatment of myeloma, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 28: (4) pp. 769-773.
type of document: Journal paper/Article
number of independent citations: 1
language: English
URL 
2018

Nemes Zoltán, Takács-Novák Krisztina, Völgyi Gergely, Valko Klara, Béni Szabolcs, Horváth Zoltán, Szokol Bálint, Breza Nóra, Dobos Judit, Szántai-Kis Csaba, Illyés Eszter, Boros Sándor, Kok Robbert Jan, Őrfi László: Synthesis and characterization of amino acid substituted sunitinib analogues for the treatment of AML, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 28: (14) pp. 2391-2398.
type of document: Journal paper/Article
language: English
URL 
2018

Szabadkai I, Torka R, Garamvolgyi R, Baska F, Gyulavari P, Boros S, Illyes E, Choidas A, Ullrich A, Orfi L: Discovery of N-[4-(Quinolin-4-yloxy)phenyl]benzenesulfonamides as Novel AXL Kinase Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY 61: (14) pp. 6277-6292.
type of document: Journal paper/Article
number of independent citations: 1
language: English
URL 
2017

Orfi Z, Waczek F, Baska F, Szabadkai I, Torka R, Hartmann J, Orfi L, Ullrich A: Novel members of quinoline compound family enhance insulin secretion in RIN-5AH beta cells and in rat pancreatic islet microtissue, SCIENTIFIC REPORTS 7: 44073
type of document: Journal paper/Article
language: English
URL 
2016

Garamvolgyi R, Dobos J, Sipos A, Boros S, Illyes E, Baska F, Kekesi L, Szabadkai I, Szantai-Kis C, Keri G, Orfi L: Design and synthesis of new imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine derivatives with antiproliferative activity against melanoma cells., EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 108: pp. 623-643.
type of document: Journal paper/Article
number of independent citations: 9
language: English
URL 
2014

Baska Ferenc, Szabadkai István, Sipos Anna, Breza Nóra, Szántai-Kis Csaba, Kékesi László, Garamvölgyi Rita, Nemes Zoltán, Baska Ferenc, Neumann Lars, Torka Robert, Ullrich Axel, Kéri György, Őrfi László: Pharmacophore and Binding Analysis of Known and Novel B-RAF Kinase Inhibitors, CURRENT MEDICINAL CHEMISTRY 21: (17) pp. 1938-1955.
type of document: Journal paper/Article
number of independent citations: 6
language: English
URL 
2010

Petak I, Schwab R, Orfi L, Kopper L, Keri G: Integrating molecular diagnostics into anticancer drug discovery, NATURE REVIEWS DRUG DISCOVERY 9: (7) pp. 523-535.
type of document: Journal paper/Article
number of independent citations: 43
language: English
URL 
2008

Zhang YX, Knyazev PG, Cheburkin YV, Sharma K, Knyazev YP, Orfi L, Szabadkai I, Daub H, Keri G, Ullrich A: AXL is a potential target for therapeutic intervention in breast cancer progression, CANCER RESEARCH 68: (6) pp. 1905-1915.
type of document: Journal paper/Article
number of independent citations: 149
language: English
URL 
2004

Ozvegy-Laczka C, Hegedus T, Varady G, Ujhelly O, Schuetz JD, Varadi A, Keri G, Orfi L, Nemet K, Sarkadi B: High-affinity interaction of tyrosine kinase inhibitors with the ABCG2multidrug transporter, MOLECULAR PHARMACOLOGY 65: (6) pp. 1485-1495.
type of document: Journal paper/Article
number of independent citations: 283
language: English
URL 
1998

Orfi L, Lin MF, Larive CK: Measurement of SDS micelle-peptide association using H-1 NMR chemical shift analysis and pulsed field gradient NMR spectroscopy, ANALYTICAL CHEMISTRY 70: (7) pp. 1339-1345.
type of document: Journal paper/Article
number of independent citations: 59
language: English
URL 
Number of independent citations to these publications:551 
Scientometric data
list of publications and citations
number of scientific publications that meet accreditation criteria:
239
number of scientific publications:
274
monographs and professional books:
0
monographs/books in which chapters/sections were contributed:
6 
art/engineering creative works:
0
scientific publications published abroad that meet the accreditation criteria:
109
publications not in Hungarian, published in Hungary, meeting the accreditation criteria:
4
number of independent citations to scientific publications and creative works:
2992
further relevant information regarding accreditation (in Hungarian)
Inventor of more than 110 pharmaceutical patents

 
All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )