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personal data approved: 2017. V. 05.
Personal data
László Őrfi
name László Őrfi
year of birth 1957
name of institution
doctoral school
BME George A. Olah Doctoral School of Chemistry and Chemical Technology (Academic staff member)
(discipline) Habilitation Comittee and Doctoral Council (external member)
SE Doctoral School of Pharmaceutical Sciences (Supervisor)
SE Doctoral School of Molecular Medicine (Announcer of research topic)
the share of work in the different doctoral schools. BME George A. Olah Doctoral School of Chemistry and Chemical Technology 10%
SE Doctoral School of Pharmaceutical Sciences 50%
SE Doctoral School of Molecular Medicine 20%
BME GAODSCC (discipline) Habilitation Comittee and Doctoral Council (external member) 20%
accreditation statement submitted to: Semmelweis University, Budapest
Contact details
E-mail address orfi.laszlopharma.semmelweis-univ.hu
phone number +36 1 217-0891
own web page
Academic title
scientific degree, title Ph.D.
year degree was obtained 1997
discipline to which degree belongs chemistry
institution granting the degree Semmelweis University
scientific degree, title Habilitation
year degree was obtained 2013
discipline to which degree belongs pharmaceutics
institution granting the degree Semmelweis University
Employment
1982 - Semmelweis University, Budapest
university professor or researcher
Thesis topic supervisor
number of doctoral students supervised until now 8
number of students who fulfilled course requirements 5
students who obtained their degrees:
Rita Garamvölgyi PhD 2017  DSPS1-SE
Ferenc Baska PhD 2015  DSPS1-SE
Gábor Németh PhD 2012  
Gábor Péter Bánhegyi PhD 2009  DSPS1-SE
Csaba Szántai-Kis PhD 2008  

students with degree granting in process:
Anna Sipos PhD (2017/08)  DSPS1-SE
Zoltán Nemes PhD (2018/12)  DSPS1-SE
present PhD students:
Mihály Szabó (PhD) (2020/08)  DSPS1-SE
Zsófia Czudor (PhD) (2018/08)  DSPS1-SE
hiányos adatú hallgatói:
Anna Sipos PhD ()  DSPS1-SE
  Thesis topic proposals
Research
research area Pharmaceutical chemistry, kinase inhibitors, quantitative structure-activity relationship (QSAR, ADMET), drug design, lead optimisation, drug discovery, medicinal chemistry, paralell synthesis
research field in which current research is conducted pharmaceutics
chemistry
Publications
2017

Ekins Sean, Godbole Adwait Anand, Kéri György, Orfi Lászlo, Pato János, Bhat Rajeshwari Subray, Verma Rinkee, Bradley Erin K, Nagaraja Valakunja: Machine learning and docking models for Mycobacterium tuberculosis topoisomerase I, TUBERCULOSIS 103: pp. 52-60.
type of document: Journal paper/Article
language: English
DOI 
2016

Hutterer C, Hamilton S, Steingruber M, Zeittrager I, Bahsi H, Thuma N, Naing Z, Orfi Z, Orfi L, Socher E, Sticht H, Rawlinson W, Chou S, Haupt VJ, Marschall M: The chemical class of quinazoline compounds provides a core structure for the design of anticytomegaloviral kinase inhibitors., ANTIVIRAL RESEARCH 134: pp. 130-143.
type of document: Journal paper/Article
language: English
DOI 
2016

Garamvolgyi R, Dobos J, Sipos A, Boros S, Illyes E, Baska F, Kekesi L, Szabadkai I, Szantai-Kis C, Keri G, Orfi L: Design and synthesis of new imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine derivatives with antiproliferative activity against melanoma cells., EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 108: pp. 623-643.
type of document: Journal paper/Article
number of independent citations: 2
language: English
DOI 
2014

Baska Ferenc, Szabadkai István, Sipos Anna, Breza Nóra, Szántai-Kis Csaba, Kékesi László, Garamvölgyi Rita, Nemes Zoltán, Baska Ferenc, Neumann Lars, Torka Robert, Ullrich Axel, Kéri György, Őrfi László: Pharmacophore and Binding Analysis of Known and Novel B-RAF Kinase Inhibitors, CURRENT MEDICINAL CHEMISTRY 21: (17) pp. 1938-1955.
type of document: Journal paper/Article
number of independent citations: 6
language: English
URL 
2012

Hegedűs C, Truta-Feles K, Antalffy G, Várady G, Német K, Özvegy-Laczka C, Kéri G, Orfi L, Szakács G, Settleman J, Váradi A, Sarkadi B: Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: Implications for the emergence and reversal of cancer drug resistance, BIOCHEMICAL PHARMACOLOGY 84: (3) pp. 260-267.
type of document: Journal paper/Article
number of independent citations: 27
language: English
DOI 
2011

Nemeth G, Varga Z, Greff Z, Bencze G, Sipos A, Szantai-Kis C, Baska F, Gyuris A, Kelemenics K, Szathmary Z, Minarovits J, Keri G, Orfi L: Novel, Selective CDK9 Inhibitors for the Treatment of HIV Infection, CURRENT MEDICINAL CHEMISTRY 18: (3) pp. 342-358.
type of document: Journal paper/Review paper
number of independent citations: 17
language: English
2010

Petak I, Schwab R, Orfi L, Kopper L, Keri G: Integrating molecular diagnostics into anticancer drug discovery, NATURE REVIEWS DRUG DISCOVERY 9: (7) pp. 523-535.
type of document: Journal paper/Article
number of independent citations: 35
language: English
DOI 
2010

Borbely G, Szabadkai I, Horvath Z, Marko P, Varga Z, Breza N, Baska F, Vantus T, Huszar M, Geiszt M, Hunyady L, Buday L, Orfi L, Keri G: Small-molecule inhibitors of NADPH oxidase 4., JOURNAL OF MEDICINAL CHEMISTRY 53: (18) pp. 6758-6762.
type of document: Journal paper/Article
number of independent citations: 28
language: English
DOI 
2008

Zhang YX, Knyazev PG, Cheburkin YV, Sharma K, Knyazev YP, Orfi L, Szabadkai I, Daub H, Keri G, Ullrich A: AXL is a potential target for therapeutic intervention in breast cancer progression, CANCER RESEARCH 68: (6) pp. 1905-1915.
type of document: Journal paper/Article
number of independent citations: 123
language: English
DOI 
2006

Szantai Kis C, Kovesdi I, Eros D, Banhegyi P, Ullrich A, Keri G, Orfi L: Prediction oriented QSAR modelling of EGFR inhibition, CURRENT MEDICINAL CHEMISTRY 13: (3) pp. 277-287.
type of document: Journal paper/Review paper
number of independent citations: 14
language: English
DOI 
Number of independent citations to these publications:252 
Scientometric data
list of publications and citations
number of scientific publications that meet accreditation criteria:
202
number of scientific publications:
259
monographs and professional books:
0
monographs/books in which chapters/sections were contributed:
2 
scientific publications published abroad that meet the accreditation criteria:
100
publications not in Hungarian, published in Hungary, meeting the accreditation criteria:
84
number of independent citations to scientific publications and creative works:
2527
further relevant information regarding accreditation (in Hungarian)
Inventor of 105 pharmaceutical patents

 
All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )