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personal data approved: 2019. XI. 24.
Personal data
name Miklós Sahin-Tóth
name of institution
doctoral school
SE Doctoral School of Molecular Medicine (Academic staff member)
SzTE Doctoral School of Interdisciplinary Medicine (Academic staff member)
SzTE Theoretical Medicine Doctoral School (Academic staff member)
the share of work in the different doctoral schools. SE Doctoral School of Molecular Medicine 20%
SzTE Doctoral School of Interdisciplinary Medicine 20%
SzTE Theoretical Medicine Doctoral School 60%
Contact details
E-mail address miklosbu.edu
Academic title
scientific degree, title Ph.D.
year degree was obtained 1994
discipline to which degree belongs theoretical medicine
institution granting the degree Semmelweis Orvostudományi Egyetem (to be translated)
scientific degree, title CSc
year degree was obtained 1994
discipline to which degree belongs theoretical medicine
institution granting the degree HAS
Employment
2019 - University of California Los Angeles
research professor
Thesis topic supervisor
number of doctoral students supervised until now 5
number of students who fulfilled course requirements 5
students who obtained their degrees:
(50%) Anna Zsófia Tóth PhD 2018  TMDS
(50%) Anita Balázs PhD 2015  TMDS
(50%) Balázs Németh PhD 2014  IDS-SzTE
(50%) Andrea Geisz PhD 2013  TMDS
(50%) Melinda Bence PhD 2012  DSMM-SE
Orsolya Király PhD 2008  DSMM-SE
Richárd Szmola PhD 2008  DSMM-SE

  Thesis topic proposals
Research
research area Pathobiochemistry of pancreatitis. Genetic risk factors in chronic pancreatitis. The role of digestive enzymes in the development of pancreatitis.
research field in which current research is conducted theoretical medicine
biology
Publications
2019

Hegyi E, Sahin-Tóth M: Human CPA1 mutation causes digestive enzyme misfolding and chronic pancreatitis in mice, GUT 68: (2) pp. 301-312.
type of document: Journal paper/Article
language: English
2018

Jancsó Z, Hegyi E, Sahin-Tóth M: Chymotrypsin Reduces the Severity of Secretagogue-induced Pancreatitis in Mice, GASTROENTEROLOGY 155: (4) pp. 1017-1021.
type of document: Journal paper/Article
language: English
2018

Geisz Andrea, Sahin-Toth Miklos: A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation, NATURE COMMUNICATIONS 9: 5033
type of document: Journal paper/Article
language: English
2016

Jancso Z, Sahin-Toth M: Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis., JOURNAL OF BIOLOGICAL CHEMISTRY 291: (25) pp. 12897-12905.
type of document: Journal paper/Article
language: English
2015

Szabo Andras, Ludwig Maren, Hegyi Eszter, Szepeova Renata, Witt Heiko, Sahin-Toth Miklos: Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis, JOURNAL OF BIOLOGICAL CHEMISTRY 290: (28) pp. 17282-17292.
type of document: Journal paper/Article
number of independent citations: 5
language: English
URL 
2014

Schnur A, Beer S, Witt H, Hegyi P, Sahin-Toth M: Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis., GUT 63: (2) pp. 337-343.
type of document: Journal paper/Article
number of independent citations: 21
language: English
DOI 
2013

Geisz A, Hegyi P, Sahin-Tóth M: Robust autoactivation, chymotrypsin C independence and diminished secretion define a subset of hereditary pancreatitis associated cationic trypsinogen mutants., FEBS JOURNAL 280: (12) pp. 2888-2899.
type of document: Journal paper/Article
number of independent citations: 2
language: English
DOI 
2013

Németh BC, Wartmann T, Halangk W, Sahin-Tóth M: Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop, JOURNAL OF BIOLOGICAL CHEMISTRY 288: (33) pp. 24049-24062.
type of document: Journal paper/Article
number of independent citations: 7
language: English
DOI 
2013

Beer S, Zhou J, Szabó A, Keiles S, Chandak GR, Witt H, Sahin-Tóth M: Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk, GUT 62: (11) pp. 1616-1624.
type of document: Journal paper/Article
number of independent citations: 3
language: English
DOI 
2012

Szabó A, Sahin-Tóth M: Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen, FEBS JOURNAL 279: (23) pp. 4283-4292.
type of document: Journal paper/Article
number of independent citations: 4
language: English
DOI 
Number of independent citations to these publications:42 
Scientometric data
list of publications and citations
number of scientific publications that meet accreditation criteria:
129
number of scientific publications:
194
monographs and professional books:
0
monographs/books in which chapters/sections were contributed:
2 
scientific publications published abroad that meet the accreditation criteria:
121
publications not in Hungarian, published in Hungary, meeting the accreditation criteria:
1
number of independent citations to scientific publications and creative works:
3125


2020. VI. 25.
ODT ülés
Az ODT következő ülésére 2020. július 10-én 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).

 
All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )