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personal data approved: 2017. VIII. 14.
Personal data
name Miklós Sahin-Tóth
year of birth 1963
name of institution
doctoral school
SE Doctoral School of Molecular Medicine (Announcer of research topic)
SzTE Doctoral School of Interdisciplinary Medicine (Academic staff member)
SzTE Theoretical Medicine Doctoral School (Academic staff member)
the share of work in the different doctoral schools. SE Doctoral School of Molecular Medicine 20%
SzTE Doctoral School of Interdisciplinary Medicine 20%
SzTE Theoretical Medicine Doctoral School 60%
Contact details
E-mail address miklosbu.edu
phone number +16174141070
Academic title
scientific degree, title Ph.D.
year degree was obtained 1994
discipline to which degree belongs theoretical medicine
institution granting the degree Semmelweis Orvostudományi Egyetem (to be translated)
scientific degree, title CSc
year degree was obtained 1994
discipline to which degree belongs theoretical medicine
institution granting the degree HAS
Employment
2002 - Boston University Medical Center (research institute, not university)
research professor
Thesis topic supervisor
number of doctoral students supervised until now 5
number of students who fulfilled course requirements 5
students who obtained their degrees:
(50%) Anita Balázs PhD 2015  TMDS
(50%) Balázs Németh PhD 2014  IDS-SzTE
(50%) Andrea Geisz PhD 2013  TMDS
(50%) Melinda Bence PhD 2012  DSMM-SE
Orsolya Király PhD 2008  DSMM-SE
Richárd Szmola PhD 2008  DSMM-SE

  Thesis topic proposals
Research
research area Pathobiochemistry of pancreatitis. Genetic risk factors in chronic pancreatitis. The role of digestive enzymes in the development of pancreatitis.
research field in which current research is conducted theoretical medicine
biology
Publications
2014

Szabo Andras, Salameh Moh'd A, Ludwig Maren, Radisky Evette S, Sahin-Toth Miklos: Tyrosine Sulfation of Human Trypsin Steers S2 ' Subsite Selectivity towards Basic Amino Acids, PLOS ONE 9: (7) Paper e102063. p.
type of document: Journal paper/Article
language: English
DOI 
2014

Szabo Andras, Radisky Evette S, Sahin-Toth Miklos: Zymogen Activation Confers Thermodynamic Stability on a Key Peptide Bond and Protects Human Cationic Trypsin from Degradation*, JOURNAL OF BIOLOGICAL CHEMISTRY 289: (8) pp. 4753-4761.
type of document: Journal paper/Article
language: English
DOI 
2014

Schnur A, Beer S, Witt H, Hegyi P, Sahin-Toth M: Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis., GUT 63: (2) pp. 337-343.
type of document: Journal paper/Article
number of independent citations: 21
language: English
DOI 
2013

Geisz A, Hegyi P, Sahin-Tóth M: Robust autoactivation, chymotrypsin C independence and diminished secretion define a subset of hereditary pancreatitis associated cationic trypsinogen mutants., FEBS JOURNAL 280: (12) pp. 2888-2899.
type of document: Journal paper/Article
number of independent citations: 2
language: English
DOI 
2013

Batra J, Szabó A, Caulfield TR, Soares AS, Sahin-Tóth M, Radisky ES: Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation, JOURNAL OF BIOLOGICAL CHEMISTRY 288: (14) pp. 9848-9859.
type of document: Journal paper/Article
number of independent citations: 1
language: English
DOI 
2013

Németh BC, Wartmann T, Halangk W, Sahin-Tóth M: Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop, JOURNAL OF BIOLOGICAL CHEMISTRY 288: (33) pp. 24049-24062.
type of document: Journal paper/Article
number of independent citations: 7
language: English
DOI 
2013

Beer S, Zhou J, Szabó A, Keiles S, Chandak GR, Witt H, Sahin-Tóth M: Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk, GUT 62: (11) pp. 1616-1624.
type of document: Journal paper/Article
number of independent citations: 3
language: English
DOI 
2012

Szabó A, Sahin-Tóth M: Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen, FEBS JOURNAL 279: (23) pp. 4283-4292.
type of document: Journal paper/Article
number of independent citations: 4
language: English
DOI 
2012

Szabó A, Sahin-Tóth M: Increased activation of hereditarypancreatitis-associated Human cationic trypsinogen mutants inpresence of chymotrypsin C, JOURNAL OF BIOLOGICAL CHEMISTRY 287: (24) pp. 20701-20710.
type of document: Journal paper/Article
number of independent citations: 11
language: English
DOI 
2011

Zhou J, Sahin-Tóth M: Chymotrypsin C mutations in chronic pancreatitis, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 26: (8) pp. 1238-1246.
type of document: Journal paper/Article
number of independent citations: 7
language: English
DOI 
Number of independent citations to these publications:56 
Scientometric data
list of publications and citations
number of scientific publications that meet accreditation criteria:
102
number of scientific publications:
146
monographs and professional books:
0
monographs/books in which chapters/sections were contributed:
2 
scientific publications published abroad that meet the accreditation criteria:
98
publications not in Hungarian, published in Hungary, meeting the accreditation criteria:
2
number of independent citations to scientific publications and creative works:
2466


2017. XI. 23.
ODT ülés
Az ODT következő ülésére 2017. december 8-án 10.00 órakor kerül sor a Semmelweis Egyetem II. Belgyógyászati Klinika tetőterében levő MSD teremben (Bp. Szentkirályi u. 46., a rektori épület mellett).

 
All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )