Login
 Forum
 
 
Personal data sheet
 Print preview
VALIDITY EXPIRED
personal data approved: 2019. IV. 15.
Personal data
name Ervin Welker
name of institution
doctoral school
BME George A. Olah Doctoral School of Chemistry and Chemical Technology (Academic staff member)
ELTE Doctoral School of Biology (Academic staff member)
SE Doctoral School of Molecular Medicine (Academic staff member)
SzTE Doctoral School of Multidisciplinary Medical Scienses (Announcer of research topic)
SzTE Doctoral School of Biology (Academic staff member)
SE Doctoral School of University Semmelweis (Supervisor)
the share of work in the different doctoral schools. BME George A. Olah Doctoral School of Chemistry and Chemical Technology 20%
ELTE Doctoral School of Biology 20%
SzTE Doctoral School of Multidisciplinary Medical Scienses 20%
SzTE Doctoral School of Biology 20%
SE Doctoral School of University Semmelweis 20%
accreditation statement submitted to: University of Szeged
Contact details
E-mail address welkerbrc.hu
phone number +36 30 415-8500
own web page
Academic title
scientific degree, title Ph.D.
year degree was obtained 1997
discipline to which degree belongs biology
institution granting the degree ELTE (to be translated)
scientific degree, title DSc
year degree was obtained 2008
discipline to which degree belongs biology
institution granting the degree HAS
Employment
2012 - Természettudományi Kutatóközpont (research institute, not university)
scientific consultant
2004 - Szegedi Biologiai Kutató Intézet (research institute, not university)
2004 - Szegedi Biologiai Kutató Intézet (research institute, not university)
scientific consultant
Thesis topic supervisor
number of doctoral students supervised until now 11
number of students who fulfilled course requirements 1
students who obtained their degrees:
(50%) Babu Sangeetham Sudheer PhD 2022  DSMMS
András Tálas PhD 2021  DSMM-SE
Nóra Weinhardt PhD 2021  USz-DSB
Péter István Kulcsár PhD 2019  DSMMS
Antal Nyeste PhD 2016  DSMMS
(50%) Pradeep Kumar Reddy Cingaram PhD 2016  USz-DSB
(50%) Eszter Tóth PhD 2015  DSB-ELTE

students with degree granting in process:
Éva Varga PhD (2024/08)  DSMMS
Zoltán Mihály Ligeti PhD (2024/08)  DSMMS
completed course requirement:
Krisztina Huszár (PhD) 2012/08  
Sarah Laura Krausz (PhD) 2020/08  DSMM-SE
present PhD students:
Dorottya Anna Simon (PhD) (2025/08)  SEDI (to be translated)
Zsuzanna Biczók (PhD) (2025/08)  SEDI (to be translated)
  Thesis topic proposals
Research
research area We are interested in developing CRISPR/Cas-based genome engineering methodologies and generating disease models and genetically modified entities in different animal/cell systems.
research field in which current research is conducted biology
Publications
2022

Simon Dorottya Anna, Tálas András, Kulcsár Péter István, Biczók Zsuzsanna, Krausz Sarah Laura, Várady György, Welker Ervin: PEAR, a flexible fluorescent reporter for the identification and enrichment of successfully prime edited cells, ELIFE 11: e69504
type of document: Journal paper/Article
language: English
URL 
2021

Tálas András, Huszár Krisztina, Kulcsár Péter István, Varga Julia K, Varga Éva, Tóth Eszter, Welker Zsombor, Erdős Gergely, Pach Péter Ferenc, Welker Ágnes, Györgypál Zoltán, Tusnády Gábor E, Welker Ervin: A method for characterizing Cas9 variants via a one-million target sequence library of self-targeting sgRNAs, NUCLEIC ACIDS RESEARCH 49: (6) e31
type of document: Journal paper/Article
number of independent citations: 2
language: English
URL 
2021

Tálas András, Simon Dorottya A., Kulcsár Péter I., Varga Éva, Krausz Sarah L., Welker Ervin: BEAR reveals that increased fidelity variants can successfully reduce the mismatch tolerance of adenine but not cytosine base editors, NATURE COMMUNICATIONS 12: (1) 6353
type of document: Journal paper/Article
language: English
URL 
2020

Tóth Eszter, Varga Éva, Kulcsár Péter István, Kocsis-Jutka Virág, Krausz Sarah Laura, Nyeste Antal, Welker Zsombor, Huszár Krisztina, Ligeti Zoltán, Tálas András, Welker Ervin: Improved LbCas12a variants with altered PAM specificities further broaden the genome targeting range of Cas12a nucleases, NUCLEIC ACIDS RESEARCH 48: (7) pp. 3722-3733.
type of document: Journal paper/Article
number of independent citations: 19
language: English
URL 
2020

Kulcsár Péter István, Tálas András, Tóth Eszter, Nyeste Antal, Ligeti Zoltán, Welker Zsombor, Welker Ervin: Blackjack mutations improve the on-target activities of increased fidelity variants of SpCas9 with 5′G-extended sgRNAs, NATURE COMMUNICATIONS 11: (1) 1223
type of document: Journal paper/Article
number of independent citations: 2
language: English
URL 
2018

Tóth Eszter, Czene Bernadett C, Kulcsár Péter I, Krausz Sarah L, Tálas András, Nyeste Antal, Varga Éva, Huszár Krisztina, Weinhardt Nóra, Ligeti Zoltán, Borsy Adrienn É, Fodor Elfrieda, Welker Ervin: Mb- and FnCpf1 nucleases are active in mammalian cells: activities and PAM preferences of four wild-type Cpf1 nucleases and of their altered PAM specificity variants, NUCLEIC ACIDS RESEARCH 46: (19) pp. 10272-10285.
type of document: Journal paper/Article
number of independent citations: 32
language: English
URL 
2017

Kulcsar PI, Talas A, Huszar K, Ligeti Z, Toth E, Weinhardt N, Fodor E, Welker E: Crossing enhanced and high fidelity SpCas9 nucleases to optimize specificity and cleavage, GENOME BIOLOGY 18: 190
type of document: Journal paper/Article
number of independent citations: 59
language: English
URL 
2016

Toth E, Weinhardt N, Bencsura P, Huszar K, Kulcsar PI, Talas A, Fodor E, Welker E: Cpf1 nucleases demonstrate robust activity to induce DNA modification by exploiting homology directed repair pathways in mammalian cells, BIOLOGY DIRECT 11: 46
type of document: Journal paper/Article
number of independent citations: 37
language: English
URL 
2008

Narayan M, Welker E, Zhai H, Han X, Xu G, McLafferty FW, Scheraga HA: Detecting native folds in mixtures of proteins that contain disulfide bonds, NATURE BIOTECHNOLOGY 26: pp. 427-429.
type of document: Journal paper/Article
number of independent citations: 7
language: English
URL 
2004

Welker E, Maki K, Shastry McR, Juminaga D, Bhat R, Scheraga HA, Roder H: Ultrarapid mixing experiments shed new light on the characteristics of the initial conformational ensemble during the folding of ribonuclease A, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101: pp. 17681-17686.
type of document: Journal paper/Article
number of independent citations: 39
language: English
URL 
2002

Wedemeyer WJ, Welker E, Scheraga HA: Proline cis-trans isomerization and protein folding, BIOCHEMISTRY 41: pp. 14637-14644.
type of document: Journal paper/Article
number of independent citations: 325
language: English
URL 
2002

Welker E, Raymond LD, Scheraga HA, Caughey B: Intramolecular versus intermolecular disulfide bonds in prion proteins, JOURNAL OF BIOLOGICAL CHEMISTRY 277: pp. 33477-33481.
type of document: Journal paper/Article
number of independent citations: 66
language: English
URL 
2001

Welker E, Narayan M, Wedemeyer WJ, Scheraga HA: Structural determinants of oxidative folding in proteins, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98: pp. 2312-2316.
type of document: Journal paper/Article
number of independent citations: 54
language: English
URL 
2001

Welker E, Wedemeyer WJ, Narayan M, Scheraga HA: Coupling of conformational folding and disulfide-bond reactions in oxidative folding of proteins, BIOCHEMISTRY 40: (31) pp. 9059-9064.
type of document: Journal paper/Article
number of independent citations: 65
language: English
URL 
2001

Welker E, Wedemeyer WJ, Scheraga HA: A role for intermolecular disulfide bonds in prion diseases?, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98: pp. 4334-4336.
type of document: Journal paper/Article
number of independent citations: 59
language: English
URL 
2000

Wedemeyer WJ, Welker E, Narayan M, Scheraga HA: Disulfide bonds and protein folding, BIOCHEMISTRY 39: pp. 4207-4216.
type of document: Journal paper/Article
number of independent citations: 461
language: English
URL 
2000

NARAYAN M, WELKER E, WEDEMEYER WJ, SCHERAGA HA: Oxidative folding of proteins, ACCOUNTS OF CHEMICAL RESEARCH 33: pp. 805-812.
type of document: Journal paper/Article
number of independent citations: 124
language: English
URL 
1998

Bakos E, Evers R, Szakács G, Tusnády GE, Welker E, Szabó K, de Haas M, van Deemter L, Borst P, Váradi A, Sarkadi B: Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain, JOURNAL OF BIOLOGICAL CHEMISTRY 273: (48) pp. 32167-32175.
type of document: Journal paper/Article
number of independent citations: 229
language: English
URL 
1996

Bakos E, Hegedűs T, Holló Z, Welker E, Tusnády GE, Zaman GJ, Flens MJ, Váradi A, Sarkadi B: Membrane topology and glycosylation of the human multidrug resistance-associated protein, JOURNAL OF BIOLOGICAL CHEMISTRY 271: (21) pp. 12322-12326.
type of document: Journal paper/Article
number of independent citations: 167
language: English
URL 
1996

Müller M, Bakos E, Welker E, Váradi A, Germann UA, Gottesman MM, Morse BS, Roninson IB, Sarkadi B: Altered drug-stimulated ATPase activity in mutants of the human multidrug resistance protein, JOURNAL OF BIOLOGICAL CHEMISTRY 271: (4) pp. 1877-1883.
type of document: Journal paper/Article
number of independent citations: 106
language: English
URL 
Number of independent citations to these publications:1853 
Scientometric data
list of publications and citations
number of scientific publications that meet accreditation criteria:
78
number of scientific publications:
77
monographs and professional books:
0
monographs/books in which chapters/sections were contributed:
0 
number of independent citations to scientific publications and creative works:
3088


2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).

 
All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )