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personal data approved: 2018. II. 08.
Personal data
name Éva Gráczer
name of institution
doctoral school
ELTE Doctoral School of Biology (Academic staff member)
Contact details
E-mail address graczer.evattk.mta.hu
phone number +36 1 382-6773
Academic title
scientific degree, title Ph.D.
year degree was obtained 2010
discipline to which degree belongs biology
institution granting the degree Eötvös Loránd University
Employment
2010 - MTA Természettudományi Kutatóközpont (research institute, not university)
other (not specified) (tudományos munkatárs)
Thesis topic supervisor
number of doctoral students supervised until now 0.5
number of students who fulfilled course requirements 0.5
students who obtained their degrees:
  Thesis topic proposals
Research
research area The research field of interest covers enzymology and protein chemistry. This includes structural reasons of thermostability and molecular mechanism of various enzymic function.
research field in which current research is conducted biology
Publications
2016

Graczer E, Szimler T, Garamszegi A, Konarev PV, Labas A, Olah J, Pallo A, Svergun DI, Merli A, Zavodszky P, Weiss MS, Vas M: Dual Role of the Active Site Residues of Thermus thermophilus 3-Isopropylmalate Dehydrogenase: Chemical Catalysis and Domain Closure., BIOCHEMISTRY 55: (3) pp. 560-574.
type of document: Journal paper/Article
number of independent citations: 1
language: English
URL 
2015

Gráczer Éva, Palló Anna, Oláh Julianna, Szimler Tamás, Konarev Petr V, Svergun Dmitri I, Merli Angelo, Závodszky Péter, Weiss Manfred S, Vas Mária: Glutamate 270 plays an essential role in K+-activation and domain closure of Thermus thermophilus isopropylmalate dehydrogenase, FEBS LETTERS 589: (2) pp. 240-245.
type of document: Journal paper/Article
number of independent citations: 1
language: English
URL 
2014

Graczer E, Bacso A, Konya D, Kazi A, Soos T, Molnar L, Szimler T, Beinrohr L, Szilagyi A, Zavodszky P, Vas M: Drugs Against Mycobacterium Tuberculosis 3-Isopropylmalate Dehydrogenase Can be Developed using Homologous Enzymes as Surrogate Targets., PROTEIN AND PEPTIDE LETTERS 21: (12) pp. 1295-1307.
type of document: Journal paper/Article
number of independent citations: 1
language: English
URL 
2014

Palló A, Oláh J, Gráczer E, Merli A, Závodszky P, Weiss MS, Vas M: Structural and energetic basis of isopropylmalate dehydrogenase enzyme catalysis, FEBS JOURNAL 281: (22) pp. 5063-5076.
type of document: Journal paper/Article
number of independent citations: 5
language: English
URL 
2013

Varga A, Gráczer É, Chaloin L, Liliom K, Závodszky P, Lionne C, Vas M: Selectivity of kinases on the activation of tenofovir, an anti-HIV agent, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 48: (1-2) pp. 307-315.
type of document: Journal paper/Article
number of independent citations: 7
language: English
DOI 
2011

Zerrad L, Merli A, Schroder GF, Varga A, Graczer E, Pernot P, Round A, Vas M, Bowler MW: A Spring-loaded Release Mechanism Regulates Domain Movement and Catalysis in Phosphoglycerate Kinase, JOURNAL OF BIOLOGICAL CHEMISTRY 286: (16) pp. 14040-14048.
type of document: Journal paper/Article
number of independent citations: 19
language: English
DOI 
2010

Vas M, Varga A, Gráczer E: Insight into the mechanism of domain movements and their role in enzyme function: example of 3-phosphoglycerate kinase., CURRENT PROTEIN AND PEPTIDE SCIENCE 11: (2) pp. 118-147.
type of document: Journal paper/Review paper
number of independent citations: 12
language: English
DOI 
2007

Graczer E, Varga A, Hajdu I, Melnik B, Szilagyi A, Semisotnov G, Zavodszky P, Vas M: Rates of unfolding, rather than refolding, determine thermal stabilities of thermophilic, mesophilic, and psychrotrophic 3-isopropylmalate dehydrogenases, BIOCHEMISTRY 46: (41) pp. 11536-11549.
type of document: Journal paper/Article
number of independent citations: 7
language: English
DOI 
2006

Varga A, Flachner B, Konarev P, Gráczer E, Szabó J, Svergun D, Závodszky P, Vas M: Substrate-induced double sided H-bond network as a means of domain closure in 3-phosphoglycerate kinase, FEBS LETTERS 580: pp. 2698-2706.
type of document: Journal paper/Article
number of independent citations: 10
language: English
DOI 
2005

Varga A, Flachner B, Graczer E, Osvath S, Szilagyi AN, Vas M: Correlation between conformational stability of the ternary enzyme-substrate complex and domain closure of 3-phosphoglycerate kinase, FEBS JOURNAL 272: (8) pp. 1867-1885.
type of document: Journal paper/Article
number of independent citations: 15
language: English
DOI 
Number of independent citations to these publications:78 
Scientometric data
list of publications and citations
number of scientific publications that meet accreditation criteria:
19
number of scientific publications:
21
monographs and professional books:
0
monographs/books in which chapters/sections were contributed:
0 
number of independent citations to scientific publications and creative works:
90

 
All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )